Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase

The Dengue Virus (DENV) non-structural protein 3 (NS3) is a multi-functional protein critical in the viral life cycle. The DENV NS3 is comprised of a serine protease domain and a helicase domain. The helicase domain itself acts as a molecular motor, either translocating in a unidirectional manner along single-stranded RNA or unwinding double-stranded RNA, processes fueled by the hydrolysis of nucleoside triphosphates. In this brief review, we summarize our contributions and ongoing efforts to uncover the thermodynamic and mechanistic functional properties of the DENV NS3 as an NTPase and helicase.

Palabras clave: NS3 , RNA , Kinetics , Molecular Dynamics

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/249222

URL: https://link.springer.com/10.1007/s12551-023-01101-5

DOI: http://dx.doi.org/10.1007/s12551-023-01101-5

Colecciones

Articulos(CIBION)
Articulos de CENTRO DE INVESTIGACIONES EN BIONANOCIENCIAS "ELIZABETH JARES ERIJMAN"

Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)

Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES

Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"

Citación

Incicco, Juan Jeremías; Cababie, Leila Alejandra; Sartor, Carolina Anyelen; Adler, Natalia Sol; Mikkelsen, Evelyn; et al.; Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase; Springer; Biophysical Reviews; 15; 4; 8-2023; 591-600

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