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dc.contributor.author
Mallea Gil, María Susana  
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Cristina, Silvia Carolina  
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Pérez Millán, María Inés  
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Rodriguez Villafañe, Ana M.  
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Ballarino, Carolina  
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Stalldecker, Graciela  
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Becu, Damasia  
dc.date.available
2017-09-21T20:59:59Z  
dc.date.issued
2009-03  
dc.identifier.citation
Mallea Gil, María Susana; Cristina, Silvia Carolina; Pérez Millán, María Inés; Rodriguez Villafañe, Ana M.; Ballarino, Carolina; et al.; Invasive Giant Prolactinoma with Loss of Therapeutic Response to Cabergoline: Expression of Angiogenic Markers; Springer; Endocrine Pathology; 20; 1; 3-2009; 35-40  
dc.identifier.issn
1046-3976  
dc.identifier.uri
http://hdl.handle.net/11336/24866  
dc.description.abstract
The present study reports the case of a 70-year-old Caucasian man who was referred to the Military Hospital of Buenos Aires for evaluation of a giant sellar-extrasellar mass with extension in the right temporal lobe and compression of the third ventricle. Patient was initially responsive to cabergoline with reduction of prolactin levels and shrinkage of tumor burden for at least 36 months. Thereafter, prolactin levels and tumor size increased even though cabergoline dosage was increased. Transcraneal surgery was performed at 56 months of treatment. Prolactin levels and tumor proliferation did not subside and the patient died 14 months later. High GH and IGF-I levels were observed in the late stages of tumor development, with no evidence of acromegalic features. Immunohistochemistry of the excised tumor revealed strong immunoreactivity for VEGF and FGF-2, two potent angiogenic factors, and CD31 (an endothelial marker) indicating high vascularization of the adenoma.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Prolactinoma  
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Dopamine Agosnist Resistance  
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Vegf  
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Biomarkers  
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Neovascularization  
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Bioquímica y Biología Molecular  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Patología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Invasive Giant Prolactinoma with Loss of Therapeutic Response to Cabergoline: Expression of Angiogenic Markers  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-09-13T20:40:41Z  
dc.identifier.eissn
1559-0097  
dc.journal.volume
20  
dc.journal.number
1  
dc.journal.pagination
35-40  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlín  
dc.description.fil
Fil: Mallea Gil, María Susana. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina  
dc.description.fil
Fil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Pérez Millán, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Rodriguez Villafañe, Ana M.. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina  
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Fil: Ballarino, Carolina. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina  
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Fil: Stalldecker, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos “Dr. Ignacio Pirovano”; Argentina  
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Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.journal.title
Endocrine Pathology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12022-009-9057-3  
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12022-009-9057-3