Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats

Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD disease patient carrying a heterozygous deletion within the C9ORF72 hexanucleotide repeat region resulting in a GGGGCCG sequence (∼1.16 repeats). C9ORF72 genotype was maintained and stemness and pluripotency confirmed in INEUi001-A hiPSC line.

Palabras clave: FRONTOTEMPORAL DEMENTIA , AMYOTROPHIC LATERAL SCLEROSIS , INDUCED PLURIPOTENT STEM CELLS

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)

Identificadores

URI: http://hdl.handle.net/11336/248615

DOI: https://doi.org/10.1016/j.scr.2023.103076

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Articulos (INEU)
Articulos de INSTITUTO DE NEUROCIENCIAS

Citación

Nievas, Micaela Alejandra; Romorini, Leonardo; Isaja, Luciana; Clas, Giulia Solange; Rodríguez Varela, Maria Soledad; et al.; Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats; Elsevier Science; Stem Cell Research; 69; 6-2023; 1-5

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