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dc.contributor.author
Bluguermann, Carolina
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dc.contributor.author
Wu, Ling
dc.contributor.author
Petrigliano, Frank
dc.contributor.author
McAllister, David
dc.contributor.author
Miriuka, Santiago Gabriel
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dc.contributor.author
Evseenko, Denis A.
dc.date.available
2017-09-20T21:32:57Z
dc.date.issued
2013-06
dc.identifier.citation
Bluguermann, Carolina; Wu, Ling; Petrigliano, Frank; McAllister, David; Miriuka, Santiago Gabriel; et al.; Novel aspects of parenchymal–mesenchymal interactions: from cell types to molecules and beyond; Wiley; Cell Biochemistry And Function; 31; 4; 6-2013; 271-280
dc.identifier.issn
0263-6484
dc.identifier.uri
http://hdl.handle.net/11336/24774
dc.description.abstract
Mesenchymal stem or stromal cells (MSCs) were initially isolated from the bone marrow and received their name on the basis of their ability to differentiate into multiple lineages such as bone, cartilage, fat and muscle. However, more recent studies suggest that MSCs residing in perivascular compartments of the small and large blood vessels play a regulatory function supporting physiologic and pathologic responses of parenchymal cells, which define the functional representation of an organ or tissue. MSCs secrete or express factors that reach neighbouring parenchymal cells via either a paracrine effect or a direct cell-to-cell interaction promoting functional activity, survival and proliferation of the parenchymal cells. Previous concept of ´epithelial-stromal´ interactions can now be widened. Given that MSC can also support hematopoietic, neuronal and other non-epithelial parenchymal lineages, terms ´parenchymal-stromal´ or ´parenchymal-mesenchymal´ interactions may better describe the supportive or ´trophic´ functions of MSC. Importantly, in many cases, MSCs specifically provide supportive microenvironment for the most primitive stem or progenitor populations and therefore can play a role as ´stem/progenitor niche´ forming cells. So far, regulatory roles of MSCs have been reported in many tissues. In this review article, we summarize the latest studies that focused on the supportive function of MSC. This thread of research leads to a new perspective on the interactions between parenchymal and mesenchymal cells and justifies a principally novel approach for regenerative medicine based on co-application of MSC and parenchymal cell for the most efficient tissue repair.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mesenchymal Stromal Cell
dc.subject
Niche
dc.subject
Parenchymal-Mesenchymal Interaction
dc.subject
Trophic Effects
dc.subject
Msc
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Novel aspects of parenchymal–mesenchymal interactions: from cell types to molecules and beyond
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-19T14:25:41Z
dc.identifier.eissn
1099-0844
dc.journal.volume
31
dc.journal.number
4
dc.journal.pagination
271-280
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Bluguermann, Carolina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Laboratorio de Biología del Desarrollo Celular; Argentina. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Wu, Ling. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Petrigliano, Frank. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: McAllister, David. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Miriuka, Santiago Gabriel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Laboratorio de Biología del Desarrollo Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Evseenko, Denis A.. University of California at Los Angeles; Estados Unidos
dc.journal.title
Cell Biochemistry And Function
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cbf.2950/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cbf.2950
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