Delivery of recombinant vaccines against bovine herpesvirus type 1 and Babesia bovis to mice using liposomes derived from egg yolk lipids

Liposomes prepared from total egg yolk lipid extracts were used to deliver experimental DNA vaccines to mice consisting of pCI-neo plasmids encoding bovine herpesvirus type 1 (BoHV-1) gD or Babesia bovis MSA-2c. A significantly higher proportion of mice in the B. bovis MSA-2c group, but not those in the BoHV-1 gD group, developed detectable immunoglobulin G responses when vaccinated with liposome encapsulated DNA in comparison with mice vaccinated with naked DNA. In both groups, antibody titres were similar between mice vaccinated with liposome encapsulated DNA and naked DNA.

Palabras clave: Dna Vaccine , Egg Yolk Liposome Encapsulation , Bovine Herpesvirus Type 1 Gd , Babesia Bovis Msa-2c , Mice

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/24766

URL: http://www.sciencedirect.com/science/article/pii/S1090023312004716

DOI: http://dx.doi.org/10.1016/j.tvjl.2012.10.036

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Citación

Rodriguez, Anabel Elisa; Zamorano, Patricia Ines; Wilkowsky, Silvina Elizabeth; Torrá, Florencia Lucia; Ferreri, Lucas; et al.; Delivery of recombinant vaccines against bovine herpesvirus type 1 and Babesia bovis to mice using liposomes derived from egg yolk lipids; Elsevier; The Veterinary Journal; 196; 3; 6-2013; 550-551

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