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dc.contributor.author
Hernandez Rivera, Gabriela
dc.contributor.author
Valdez, Hugo Alberto
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Arango Ospina, Marcela
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Delgado, Juan Francisco
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Aguilar Rabiela, Arturo E.
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Gorgojo, Juan Pablo
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Zhang, Huijun
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Beltrán, Ana M.
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Boccaccini, Aldo R.
dc.contributor.author
Sanchez, Mirna Lorena
dc.date.available
2024-11-07T12:12:50Z
dc.date.issued
2024-09
dc.identifier.citation
Hernandez Rivera, Gabriela; Valdez, Hugo Alberto; Arango Ospina, Marcela; Delgado, Juan Francisco; Aguilar Rabiela, Arturo E.; et al.; PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing; Editions Sante; Journal of Drug Delivery Science and Technology; 101; 106235; 9-2024; 1-44
dc.identifier.issn
1773-2247
dc.identifier.uri
http://hdl.handle.net/11336/247560
dc.description.abstract
Astaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulation of AST into hydrogels. This study focuses on innovating the wound healing potential of AST-containing hydrogels by introducing silicate mesoporous bioactive glass nanoparticles (MBGNs). These nanoparticles release biologically active ions that accelerate cell proliferation and migration. The results showcase an innovative synergistic effect between 1 μg/mL of AST with 100 μg/mL of MBGNs, outperforming the individual proliferation effect of AST or MBGNs alone. Separately, these compounds were encapsulated in physical and chemical cross-linked hydrogel for the compound protection and delivery, finding that PVA-gelatine hydrogels are a suitable matrix for the delivery of AST and MBGNs. Physically crosslinked hydrogels showed particularly convenient characteristics for potential clinical implementation while maintaining the synergetic effect of AST and MBGNs. Although chemically crosslinked hydrogels exhibited suitable characteristics as a vehicle for AST in biological assays, cell proliferation was reduced by 57 %. The results of this research open avenues for exploring the development of new composite matrices for the co-delivery of phytochemicals and MBGNs for cutting-edge biomedical applications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Editions Sante
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
hydrogels
dc.subject
astaxanthin
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bioactive glass
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wound healing
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-10-10T11:08:37Z
dc.journal.volume
101
dc.journal.number
106235
dc.journal.pagination
1-44
dc.journal.pais
Francia
dc.description.fil
Fil: Hernandez Rivera, Gabriela. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Instituto Tecnológico de Monterrey; México. Universitat Erlangen Nuremberg; Alemania
dc.description.fil
Fil: Valdez, Hugo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
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Fil: Arango Ospina, Marcela. Universitat Erlangen Nuremberg; Alemania
dc.description.fil
Fil: Delgado, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
dc.description.fil
Fil: Aguilar Rabiela, Arturo E.. Universitat Erlangen Nuremberg; Alemania
dc.description.fil
Fil: Gorgojo, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
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Fil: Zhang, Huijun. Universitat Erlangen Nuremberg; Alemania
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Fil: Beltrán, Ana M.. Universidad de Sevilla; España
dc.description.fil
Fil: Boccaccini, Aldo R.. Universitat Erlangen Nuremberg; Alemania
dc.description.fil
Fil: Sanchez, Mirna Lorena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Universitat Erlangen Nuremberg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal of Drug Delivery Science and Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1773224724009043
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jddst.2024.106235
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