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dc.contributor.author
Errasti, María Eugenia
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dc.contributor.author
Caffini, Nestor Oscar
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dc.contributor.author
Pelzer, Lilian Eugenia
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dc.contributor.author
Rotelli, Alejandra Ester
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dc.date.available
2017-09-19T19:53:38Z
dc.date.issued
2014-01
dc.identifier.citation
Errasti, María Eugenia; Caffini, Nestor Oscar; Pelzer, Lilian Eugenia; Rotelli, Alejandra Ester; Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats; Verlag Z Naturforsch; Zeitschrift Fur Naturforschung C-a Journal Of Biosciences; 68; 11-12; 1-2014; 445-452
dc.identifier.issn
0939-5075
dc.identifier.uri
http://hdl.handle.net/11336/24639
dc.description.abstract
Several species of the family Bromeliaceae are characterized by the production of proteases in unusual amounts, especially in fruits. Bromelain, an extract rich in cysteine endopeptidases obtained from Ananas comosus L., and a few other proteases have been used as anti-infl ammatory agents for some years, but bromelain is still mainly being used as alternative and/or complementary therapy to the treatment with glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. In this study, the anti-infl ammatory action of a partially purifi ed extract from Pseudananas macrodontes (Morr.) Harms fruits (PPEPm) is presented, whose main components are cysteine endopeptidases. The effect of PPEPm was assessed in carrageenan-induced and serotonin-induced rat paw edema, as well as in the cotton pellet granuloma model. Doses with equal proteolytic activity of PPEPm and bromelain produced signifi cantly similar anti-infl ammatory responses in the acute infl ammatory models assayed, supporting the hypothesis that proteolytic activity could be responsible for the anti-infl ammatory action. On the contrary, comparable anti-infl ammatory effects of PPEPm and bromelain in the chronic infl ammatory assay required a much lower proteolytic activity content of PPEPm, which could be due to a differential affi nity for the protein target involved in this process.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Verlag Z Naturforsch
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anti-Infl Ammatory
dc.subject
Pseudananas Macrodontes
dc.subject
Plant Proteases
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-18T14:32:07Z
dc.journal.volume
68
dc.journal.number
11-12
dc.journal.pagination
445-452
dc.journal.pais
Alemania
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dc.journal.ciudad
Tübingen
dc.description.fil
Fil: Errasti, María Eugenia. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Caffini, Nestor Oscar. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; Argentina
dc.description.fil
Fil: Pelzer, Lilian Eugenia. Universidad Nacional de San Luis; Argentina
dc.description.fil
Fil: Rotelli, Alejandra Ester. Universidad Nacional de San Luis; Argentina
dc.journal.title
Zeitschrift Fur Naturforschung C-a Journal Of Biosciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.znaturforsch.com/ac/v68c/c68c.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.znaturforsch.com/s68c/s68c0445.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.znaturforsch.com/ac/v68c/68c0445.pdf
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