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Artículo

Zoonotic cycle of American Trypanosomiasis in an endemic region of the Argentine Chaco, factors that influenced a paradigm shift

Gómez Bravo, Andrea; Cirignoli, Sebastián; Wehrendt, Diana PatriciaIcon ; Schijman, Alejandro GabrielIcon ; León, Cielo M.; Flores Chaves, María; Nieto, Javier; Kieran, Troy J.; Abril, Marcelo; Guhl, Felipe
Fecha de publicación: 25/06/2024
Editorial: MDPI
Revista: Insects
e-ISSN: 2075-4450
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Trypanosoma cruzi, the causative agent of Chagas disease (American trypanosomiasis), is a highly complex zoonosis that is present throughout South America, Central America, and Mexico. The transmission of this disease is influenced by various factors, including human activities like deforestation and land use changes, which may have altered the natural transmission cycles and their connection to the environment. In this study conducted in the Argentine Chaco region, we examined the transmission dynamics of T. cruzi by collecting blood samples from wild and domestic animals, as well as triatomine bugs from human dwellings, across five sites of varying anthropic intervention. Samples were analyzed for T. cruzi infection via qPCR, and we additionally examined triatomines for bloodmeal analysis via NGS amplicon sequencing. Our analysis revealed a 15.3% infection rate among 20 wild species (n = 123) and no T. cruzi presence in 9 species of domestic animals (n = 1359) or collected triatomines via qPCR. Additionally, we found chicken (34.28%), human (21.59%), and goat (19.36%) as the predominant bloodmeal sources across all sites. These findings suggest that anthropic intervention and other variables analyzed may have directly impacted the spillover dynamics of T. cruzi´s sylvatic cycle and potentially reduced its prevalence in human habitats.
Palabras clave: CHAGAS DISEASE , TRYPANOSOMA CRUZI , HUMAN INTERVENTION , SPILLOVER , TRIATOMITES , VECTOR CONTROL , ZOONOSIS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/246114
URL: https://www.mdpi.com/2075-4450/15/7/471
DOI: http://dx.doi.org/10.3390/insects15070471
Colecciones
Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Citación
Gómez Bravo, Andrea; Cirignoli, Sebastián; Wehrendt, Diana Patricia; Schijman, Alejandro Gabriel; León, Cielo M.; et al.; Zoonotic cycle of American Trypanosomiasis in an endemic region of the Argentine Chaco, factors that influenced a paradigm shift; MDPI; Insects; 15; 7; 25-6-2024; 1-20
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