Artículo

Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness

Rojas, Paola AndreaIcon ; May, MariaIcon ; Sequeira, Gonzalo RicardoIcon ; Elia, Andres MaximilianoIcon ; Alvarez, Michelle; Martínez, Paula; González, Pedro; Hewitt, Stephen; He, Xiaping; Perou, Charles M.; Molinolo, Alfredo; Gibbons, Luz; Abba, Martín CarlosIcon ; Gass, Hugo; Lanari, Claudia Lee MalvinaIcon
Fecha de publicación: 07/2017
Editorial: Oxford Univ Press Inc
Revista: Journal Of The National Cancer Institute.
ISSN: 0027-8874
e-ISSN: 1460-2105
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Compelling evidence shows that progestins regulate breast cancer growth. Using preclinical models, we demonstrated that antiprogestins are inhibitory when the level of progesterone receptor isoform A (PR-A) is higher than that of isoform B (PR-B) and that they might stimulate growth when PR-B is predominant. The aims of this study were to investigate ex vivo responses to mifepristone (MFP) in breast carcinomas with different PR isoform ratios and to examine their clinical and molecular characteristics.
Palabras clave: Receptor de Progesterona , Antiprogestageno , Cancer de Mama , Isoforma A , Breast Neoplasms , Progestins
 
Archivos asociados
Thumbnail
 
Tamaño: 2.560Mb
Formato: PDF
.
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/24588
URL: https://academic.oup.com/jnci/article-abstract/109/7/djw317/3064537/Progesterone
DOI: https://doi.org/10.1093/jnci/djw317
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Rojas, Paola Andrea; May, Maria; Sequeira, Gonzalo Ricardo; Elia, Andres Maximiliano; Alvarez, Michelle; et al.; Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 109; 7; 7-2017; 1-9
Compartir
Altmétricas