Artículo

Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness

Rojas, Paola AndreaIcon ; May, MariaIcon ; Sequeira, Gonzalo RicardoIcon ; Elia, Andres MaximilianoIcon ; Alvarez, Michelle; Martínez, Paula; González, Pedro; Hewitt, Stephen; He, Xiaping; Perou, Charles M.; Molinolo, Alfredo; Gibbons, Luz; Abba, Martín CarlosIcon ; Gass, Hugo; Lanari, Claudia Lee MalvinaIcon
Fecha de publicación: 07/2017
Editorial: Oxford Univ Press Inc
Revista: Journal Of The National Cancer Institute.
ISSN: 0027-8874
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Compelling evidence shows that progestins regulate breast cancer growth. Using preclinical models, we demonstrated that antiprogestins are inhibitory when the level of progesterone receptor isoform A (PR-A) is higher than that of isoform B (PR-B) and that they might stimulate growth when PR-B is predominant. The aims of this study were to investigate ex vivo responses to mifepristone (MFP) in breast carcinomas with different PR isoform ratios and to examine their clinical and molecular characteristics.

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https://academic.oup.com/jnci/article-abstract/109/7/djw317/3064537/Progesterone
https://doi.org/10.1093/jnci/djw317
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Citación: Rojas, Paola Andrea; May, Maria; Sequeira, Gonzalo Ricardo; Elia, Andres Maximiliano; Alvarez, Michelle; et al.; Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 109; 7; 7-2017; 1-9
URI: http://hdl.handle.net/11336/24588
 

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