Mostrar el registro sencillo del ítem
dc.contributor.author
Ferreyra, Susana Gisela
dc.contributor.author
Sosa Lochedino, Arianna Lourdes
dc.contributor.author
Gamarra Luques, Carlos Diego
dc.contributor.author
Camargo, Alejandra Beatriz
dc.contributor.author
Fontana, Ariel Ramón
dc.date.available
2024-09-27T10:02:09Z
dc.date.issued
2024-09
dc.identifier.citation
Ferreyra, Susana Gisela; Sosa Lochedino, Arianna Lourdes; Gamarra Luques, Carlos Diego; Camargo, Alejandra Beatriz; Fontana, Ariel Ramón; In vitro cytotoxicity assessment of phenolic extracts from grapevine bunch stem and cane by-products for their potential use as phytotherapeutic agents; Open Exploration; Exploration of Foods and Foodomics; 2; 5; 9-2024; 525-541
dc.identifier.uri
http://hdl.handle.net/11336/245087
dc.description.abstract
Aim: In the present study, bunch stem and cane extracts (Vitis vinifera L. cv. Malbec) rich in phenolic compounds (PCs) like flavonoids, phenolic acids, and stilbenes are studied as potential anticancer candidates.Methods: Twenty-three PCs were quantified by liquid chromatography-diode array fluorescence detection (LC-DAD-FLD). In vitro cytotoxic activity of both extracts on healthy (HBL-100) and colorectal cancer (HCT-116) human cell lines was assessed by 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction assay.Results: Cane extract did not show cytotoxic effect for the tested lines, which can be considered as an advantage for its application in the pharmaceutical industry. Conversely, the bunch stem extract showed a dose-dependent cytotoxic effect on HCT-116 and an IC50 of 680 µg/mL after 48 h of incubation; but not reported cytotoxic activity on the healthy cell line, evidencing a beneficial selective activity. The reported results encourage further investigation of these extracts as potential preventive and/or therapeutic drugs, or their combined use with chemotherapeutic treatments that lead to a potential dose reduction.Conclusions: The results preliminarily demonstrated that the extracts have potential anticancer properties or do not cause damage at the cellular level, encouraging their application as functional/nutraceutical or phytotherapeutic agents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Open Exploration
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BIOACTIVE POLYPHENOLS
dc.subject
CYTOTOXICITY
dc.subject
GRAPEVINE BY-PRODUCTS
dc.subject
ANTICANCER ACTIVITY
dc.subject
PHYTOTHERAPEUTIC AGENTS
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
In vitro cytotoxicity assessment of phenolic extracts from grapevine bunch stem and cane by-products for their potential use as phytotherapeutic agents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-09-17T11:13:16Z
dc.identifier.eissn
2837-9020
dc.journal.volume
2
dc.journal.number
5
dc.journal.pagination
525-541
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Ferreyra, Susana Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
dc.description.fil
Fil: Sosa Lochedino, Arianna Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Gamarra Luques, Carlos Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Camargo, Alejandra Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
dc.description.fil
Fil: Fontana, Ariel Ramón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
dc.journal.title
Exploration of Foods and Foodomics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.explorationpub.com/Journals/eff/Article/101049
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.37349/eff.2024.00049
Archivos asociados