Artículo
A disynaptic feedback network activated by experience promotes the integration of new granule cells
Alvarez, Diego
; Giacomini, Damiana Paula
; Yang, Sung Min
; Trinchero, Mariela Fernanda
; Temprana, Silvio Gabriel
; Büttner, Karina A.; Beltramone, Natalia
; Schinder, Alejandro Fabián
Fecha de publicación:
10/2016
Editorial:
American Association for the Advancement of Science
Revista:
Science
ISSN:
0036-8075
e-ISSN:
1095-9203
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
Experience shapes the development and connectivity of adult-born granule cells (GCs) through mechanisms that are poorly understood. We examined the remodeling of dentate gyrus microcircuits in mice in an enriched environment (EE). Short exposure to EE during early development of new GCs accelerated their functional integration. This effect was mimicked by in vivo chemogenetic activation of a limited population of mature GCs. Slice recordings showed that mature GCs recruit parvalbumin γ-aminobutyric acid-releasing interneurons (PV-INs) that feed back onto developing GCs. Accordingly, chemogenetic stimulation of PV-INs or direct depolarization of developing GCs accelerated GC integration, whereas inactivation of PV-INs prevented the effects of EE. Our results reveal a mechanism for dynamic remodeling in which experience activates dentate networks that "prime" young GCs through a disynaptic feedback loop mediated by PV-INs.
Palabras clave:
Adult Neurogenesis
,
Disynaptic Feedback
,
Experience
,
Dentate Gyrus
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Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Alvarez, Diego; Giacomini, Damiana Paula; Yang, Sung Min; Trinchero, Mariela Fernanda; Temprana, Silvio Gabriel; et al.; A disynaptic feedback network activated by experience promotes the integration of new granule cells; American Association for the Advancement of Science; Science; 354; 6311; 10-2016; 459-465
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