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dc.contributor.author
Filer, Andrew D.  
dc.contributor.author
Bik, Magdalena  
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Parsonage, Greg N.  
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Fitton, John  
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Trebilcock, Emily  
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Howlett, Katherine  
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Raza, Karin  
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Simomns, David L.  
dc.contributor.author
Thomas, Andrew M.  
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Salmon, Mike  
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Scheel Toellner, Dagmar  
dc.contributor.author
Lord, Janet M.  
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Rabinovich, Gabriel Adrián  
dc.contributor.author
Buckley, Christopher D.  
dc.date.available
2017-09-18T19:14:44Z  
dc.date.issued
2009-05  
dc.identifier.citation
Filer, Andrew D.; Bik, Magdalena; Parsonage, Greg N.; Fitton, John; Trebilcock, Emily; et al.; Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways; Wiley; Arthritis And Rheumatism; 60; 6; 5-2009; 1604-1614  
dc.identifier.issn
0004-3591  
dc.identifier.uri
http://hdl.handle.net/11336/24480  
dc.description.abstract
High expression of galectin 3 at sites of joint destruction in rheumatoid arthritis (RA) suggests that galectin 3 plays a role in RA pathogenesis. Previous studies have demonstrated the effects of galectins on immune cells, such as lymphocytes and macrophages. This study was undertaken to investigate the hypothesis that galectin 3 induces proinflammatory effects in RA by modulating the pattern of cytokine and chemokine production in synovial fibroblasts. Matched samples of RA synovial and skin fibroblasts were pretreated with galectin 3 or tumor necrosis factor alpha (TNFalpha), and the levels of a panel of cytokines, chemokines, and matrix metalloproteinases (MMPs) were determined using enzyme-linked immunosorbent assays and multiplex assays. Specific inhibitors were used to dissect signaling pathways, which were confirmed by Western blotting and NF-kappaB activation assay.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Synovia  
dc.subject
Rheumatoid Arthritis  
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Galectin-3  
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Cytokines  
dc.subject.classification
Bioquímica y Biología Molecular  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Patología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-09-13T20:40:17Z  
dc.identifier.eissn
1529-0131  
dc.journal.volume
60  
dc.journal.number
6  
dc.journal.pagination
1604-1614  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Hoboken  
dc.description.fil
Fil: Filer, Andrew D.. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Bik, Magdalena. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Parsonage, Greg N.. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Fitton, John. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Trebilcock, Emily. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Howlett, Katherine. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Raza, Karin. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Simomns, David L.. Cellzome UK; Reino Unido  
dc.description.fil
Fil: Thomas, Andrew M.. NHS Foundation Trust; Reino Unido  
dc.description.fil
Fil: Salmon, Mike. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Scheel Toellner, Dagmar. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Lord, Janet M.. University of Birmingham; Reino Unido  
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Buckley, Christopher D.. University of Birmingham; Reino Unido  
dc.journal.title
Arthritis And Rheumatism  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/art.24574/abstract  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/art.24574  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116228/