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dc.contributor.author
Cordo Russo, Rosalia Ines
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García, Mariana Gabriela
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Barrientos, Gabriela Laura
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Orsal, A. S.
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Viola, M.
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Moschansky, Petra
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Ringel, F.
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Passi, A.
dc.contributor.author
Alaniz, Laura Daniela
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Hajos, Silvia Elvira
dc.contributor.author
Blois, Sandra M.
dc.date.available
2017-09-18T16:13:33Z
dc.date.issued
2008-11
dc.identifier.citation
Cordo Russo, Rosalia Ines; García, Mariana Gabriela; Barrientos, Gabriela Laura; Orsal, A. S.; Viola, M.; et al.; Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface; Elsevier; Placenta; 30; 1; 11-2008; 88-95
dc.identifier.issn
0143-4004
dc.identifier.uri
http://hdl.handle.net/11336/24466
dc.description.abstract
The remodelling of the endometrial architecture is fundamental to create a suitable environment for the establishment of pregnancy. During this process, substantial alterations in the composition of maternal extracellular matrix play an important role by providing a prosperous medium for implantation as well as modulating trophoblast invasion leading to the formation of a functional placental unit. Hyaluronan is a conspicuous component of the extracellular matrix, particularly in remodelling tissues undergoing regeneration and repair. During gestation, changes in HA deposition and distribution indicate that this molecule may participate in preparation of the endometrial stroma for reception and implantation of the embryo. However, little is known about the role of hyaluronan at the fetomaternal interface, specially regarding its influence in pregnancy outcome. In the present study we show increased decidual hyaluronan levels in spontaneous abortion compared with normal pregnancy mice on gestation day 7.5. Both in normal and pathologic pregnancies, high molecular size hyaluronan was found at the fetomaternal unit. However, hyaluronan metabolism (which results from the activity of hyaluronan synthases and hyaluronidases) seems to be altered in spontaneous abortion as shown by a decrease in Hyal-3 expression as well as by differences in hyaluronan molecular size spectrum. This alteration in hyaluronan metabolism in spontaneous abortion could explain its increased concentration observed in decidua and the abnormal distribution of hyaluronan around the embryo implantation crypt. Thus, increased decidual hyaluronan levels resulting from abnormal deposition and turn over may contribute to the pathogenesis of pregnancy failure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Hyaluronan
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Hyaluronan Molecular Size
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Hyaluronan Synthases
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Hyaluronidases
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Murine Pregnancy
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-13T16:15:26Z
dc.identifier.eissn
1532-3102
dc.journal.volume
30
dc.journal.number
1
dc.journal.pagination
88-95
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; Alemania
dc.description.fil
Fil: García, Mariana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; Alemania
dc.description.fil
Fil: Barrientos, Gabriela Laura. Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Orsal, A. S.. Universität zu Berlin; Alemania
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Fil: Viola, M.. Universita degli Studi dell’Insubria; Italia
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Fil: Moschansky, Petra. Universität zu Berlin; Alemania
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Fil: Ringel, F.. Universität zu Berlin; Alemania
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Fil: Passi, A.. Universita degli Studi dell’Insubria; Italia
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Fil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
dc.description.fil
Fil: Blois, Sandra M.. Universität zu Berlin; Alemania
dc.journal.title
Placenta
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.placentajournal.org/article/S0143-4004(08)00364-0/fulltext
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.placenta.2008.10.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0143400408003640
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