Mostrar el registro sencillo del ítem

dc.contributor.author
Pandiperumal, S.  
dc.contributor.author
Trakht, I.  
dc.contributor.author
Srinivasan, V.  
dc.contributor.author
Spence, D.  
dc.contributor.author
Maestroni, G.  
dc.contributor.author
Zisapel, N.  
dc.contributor.author
Cardinali, Daniel Pedro  
dc.date.available
2024-09-19T12:20:12Z  
dc.date.issued
2008-07  
dc.identifier.citation
Pandiperumal, S.; Trakht, I.; Srinivasan, V.; Spence, D.; Maestroni, G.; et al.; Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 85; 3; 7-2008; 335-353  
dc.identifier.issn
0301-0082  
dc.identifier.uri
http://hdl.handle.net/11336/244606  
dc.description.abstract
Melatonin, an endogenous signal of darkness, is an important component of the body’s internal timekeeping system. As such it regulates major physiological processes including the sleep wake cycle, pubertal development and seasonal adaptation. In addition to its relevant antioxidant activity, melatonin exerts many of its physiological actions by interacting with membrane MT1 and MT2 receptors and intracellular proteins such as quinone reductase 2, calmodulin, calreticulin and tubulin. Here we review the current knowledge about the properties and signaling of melatonin receptors as well as their potential role in health and some diseases. Melatonin MT1 and MT2 receptors are G protein coupled receptors which are expressed in various parts of the CNS (suprachiasmatic nuclei, hippocampus, cerebellar cortex, prefrontal cortex, basal ganglia, substantia nigra, ventral tegmental area, nucleus accumbens and retinal horizontal, amacrine and ganglion cells) and in peripheral organs (blood vessels, mammary gland, gastrointestinal tract, liver, kidney and bladder, ovary, testis, prostate, skin and the immune system). Melatonin receptors mediate a plethora of intracellular effects depending on the cellular milieu. These effects comprise changes in intracellular cyclic nucleotides (cAMP, cGMP) and calcium levels, activation of certain protein kinase C subtypes, intracellular localization of steroid hormone receptors and regulation of G protein signaling proteins. There are circadian variations in melatonin receptors and responses. Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer’s and Parkinson’s diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma. This paper reviews the evidence concerning melatonin receptors and signal transduction pathways in various organs. It further considers their relevance to circadian physiology and pathogenesis of certain human diseases, with a focus on the brain, the cardiovascular and immune systems, and cancer.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
MELATONIN  
dc.subject
MELATONIN RECEPTORS  
dc.subject
SUPRACHIASMATIC NUCLEUS  
dc.subject
BLOOD VESSELS  
dc.subject
IMMUNE SYSTEM  
dc.subject
PROSTATE  
dc.subject
MAMMARY GLANDS  
dc.subject
ALZHEIMER´S DISEASE  
dc.subject
PARKINSON´S DISEASE  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-09-18T13:18:19Z  
dc.journal.volume
85  
dc.journal.number
3  
dc.journal.pagination
335-353  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Pandiperumal, S.. Columbia University; Estados Unidos  
dc.description.fil
Fil: Trakht, I.. Columbia University; Estados Unidos  
dc.description.fil
Fil: Srinivasan, V.. University Sains Malaysia; Malasia  
dc.description.fil
Fil: Spence, D.. No especifíca;  
dc.description.fil
Fil: Maestroni, G.. No especifíca;  
dc.description.fil
Fil: Zisapel, N.. Universitat Tel Aviv; Israel  
dc.description.fil
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina  
dc.journal.title
Progress In Neurobiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008208000348  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pneurobio.2008.04.001