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dc.contributor.author
Maguid, Sandra Liliana
dc.contributor.author
Fernández Alberti, Sebastián
dc.contributor.author
Parisi, Gustavo Daniel
dc.contributor.author
Echave, Julian
dc.date.available
2024-09-17T10:44:46Z
dc.date.issued
2006-12
dc.identifier.citation
Maguid, Sandra Liliana; Fernández Alberti, Sebastián; Parisi, Gustavo Daniel; Echave, Julian; Evolutionary conservation of protein backbone flexibility; Springer; Journal Of Molecular Evolution; 63; 4; 12-2006; 448-457
dc.identifier.issn
0022-2844
dc.identifier.uri
http://hdl.handle.net/11336/244396
dc.description.abstract
Internal protein dynamics is essential for biological function. During evolution, protein divergence is functionally constrained: properties more relevant for function vary more slowly than less important properties. Thus, if protein dynamics is relevant for function, it should be evolutionary conserved. In contrast with the well-studied evolution of protein structure, the evolutionary divergence of protein dynamics has not been addressed systematically before, apart from a few case studies. X-Ray diffraction analysis gives information not only on protein structure but also on B-factors, which characterize the flexibility that results from protein dynamics. Here we study the evolutionary divergence of protein backbone dynamics by comparing the Ca flexibility (B-factor) profiles for a large dataset of homologous proteins classified into families and superfamilies. We show that Ca flexibility profiles diverge slowly, so that they are conserved at family and superfamily levels, even for pairs of proteins with nonsignificant sequence similarity. We also analyze and discuss the correlations among the divergences of flexibility, sequence, and structure.a flexibility (B-factor) profiles for a large dataset of homologous proteins classified into families and superfamilies. We show that Ca flexibility profiles diverge slowly, so that they are conserved at family and superfamily levels, even for pairs of proteins with nonsignificant sequence similarity. We also analyze and discuss the correlations among the divergences of flexibility, sequence, and structure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FLEXIBILITY
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PROTEIN EVOLUTION
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B-FACTORS
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CONSERVATION
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Otras Ciencias Naturales y Exactas
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Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Evolutionary conservation of protein backbone flexibility
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-09-13T11:34:03Z
dc.journal.volume
63
dc.journal.number
4
dc.journal.pagination
448-457
dc.journal.pais
Alemania
dc.description.fil
Fil: Maguid, Sandra Liliana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: Fernández Alberti, Sebastián. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Echave, Julian. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.journal.title
Journal Of Molecular Evolution
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00239-005-0209-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00239-005-0209-x
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