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dc.contributor.author
Vitale, Daiana Luján
dc.contributor.author
Parnigoni, Arianna
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Viola, Manuela
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Karousou, Evgenia
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Sevic, Ina
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Moretto, Paola
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Passi, Alberto
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Alaniz, Laura Daniela
dc.contributor.author
Vigetti, Davide
dc.date.available
2024-09-10T14:58:28Z
dc.date.issued
2024-07
dc.identifier.citation
Vitale, Daiana Luján; Parnigoni, Arianna; Viola, Manuela; Karousou, Evgenia; Sevic, Ina; et al.; Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 14; 7-2024; 1-19
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/243988
dc.description.abstract
Hyaluronan (HA) has gained significant attention in cancer research for its role in modulating chemoresistance. This review aims to elucidate the mechanisms by which HA contributes to chemoresistance, focusing on its interactions within the tumor microenvironment. HA is abundantly present in the extracellular matrix (ECM) and binds to cell-surface receptors such as CD44 and RHAMM. These interactions activate various signaling pathways, including PI3K/Akt, MAPK, and NF-κB, which are implicated in cell survival, proliferation, and drug resistance. HA also influences the physical properties of the tumor stroma, enhancing its density and reducing drug penetration. Additionally, HA-mediated signaling contributes to the epithelial–mesenchymal transition (EMT), a process associated with increased metastatic potential and resistance to apoptosis. Emerging therapeutic strategies aim to counteract HA-induced chemoresistance by targeting HA synthesis, degradation, metabolism, or its binding to CD44. This review underscores the complexity of HA’s role in chemoresistance and highlights the potential for HA-targeted therapies to improve the efficacy of conventional chemotherapeutics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
HYALURONAN
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HAS2
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HAS2-AS1
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UGDH
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CHEMOTHERAPY
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DRUG RESISTANCE
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4-MU
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-13T12:27:50Z
dc.journal.volume
25
dc.journal.number
14
dc.journal.pagination
1-19
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Parnigoni, Arianna. Uppsala Universitet; Suecia
dc.description.fil
Fil: Viola, Manuela. Universitá Degli Studi Dell´insubria; Italia
dc.description.fil
Fil: Karousou, Evgenia. Universitá Degli Studi Dell´insubria; Italia
dc.description.fil
Fil: Sevic, Ina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Moretto, Paola. Universitá Degli Studi Dell´insubria; Italia
dc.description.fil
Fil: Passi, Alberto. Universitá Degli Studi Dell´insubria; Italia
dc.description.fil
Fil: Alaniz, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Vigetti, Davide. Universitá Degli Studi Dell´insubria; Italia
dc.journal.title
International Journal of Molecular Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/25/14/7607
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms25147607
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