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dc.contributor.author Palacios, María Gabriela
dc.contributor.author Cunnick, Joan E.
dc.contributor.author Winkler, David W.
dc.contributor.author Vleck, Carol M.
dc.date.available 2017-09-15T16:15:33Z
dc.date.issued 2011-12-12
dc.identifier.citation Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.; Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate; University of Chicago Press; Physiological and Biochemical Zoology; 85; 1; 12-12-2011; 1-10
dc.identifier.issn 1522-2152
dc.identifier.uri http://hdl.handle.net/11336/24363
dc.description.abstract Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology.
dc.format application/pdf
dc.language.iso eng
dc.publisher University of Chicago Press
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Complement
dc.subject Ecological immunology
dc.subject Immunocompetence
dc.subject Lymphocyte proliferation
dc.subject Natural antibodies
dc.subject Phytohemagglutinin
dc.subject Tachycineta bicolor
dc.subject Trade-off
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-09-07T16:51:48Z
dc.journal.volume 85
dc.journal.number 1
dc.journal.pagination 1-10
dc.journal.pais Estados Unidos
dc.journal.ciudad Chicago
dc.description.fil Fil: Palacios, María Gabriela. Iowa State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Cunnick, Joan E.. Iowa State University; Estados Unidos
dc.description.fil Fil: Winkler, David W.. Cornell University; Estados Unidos
dc.description.fil Fil: Vleck, Carol M.. Iowa State University; Estados Unidos
dc.journal.title Physiological and Biochemical Zoology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.journals.uchicago.edu/doi/10.1086/663311
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1086/663311


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)