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dc.contributor.author
Calabrese, Ana  
dc.contributor.author
Fraiman, Daniel  
dc.contributor.author
Zysman, Daniel  
dc.contributor.author
Ponce Dawson, Silvina Martha  
dc.date.available
2024-09-03T11:39:43Z  
dc.date.issued
2010-09  
dc.identifier.citation
Calabrese, Ana; Fraiman, Daniel; Zysman, Daniel; Ponce Dawson, Silvina Martha; Stochastic fire-diffuse-fire model with realistic cluster dynamics; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 82; 3; 9-2010; 319101-3191012  
dc.identifier.issn
1063-651X  
dc.identifier.uri
http://hdl.handle.net/11336/243447  
dc.description.abstract
Living organisms use waves that propagate through excitable media totransport information. Ca2+ waves are a paradigmatic example of thistype of processes. A large hierarchy of Ca2+ signals that range fromlocalized release events to global waves has been observed in Xenopus laevisoocytes.  In these cells, Ca2+ release occurs troughinositol 1,4,5-trisphosphate receptors (IP3R´s) which are organizedin clusters of channels located on the membrane of the endoplasmicreticulum. In this article we construct a stochastic model for acluster of IP3R´s that replicates the experimental observationsreported in Fraiman et al, Biophys. J. 90, 3897(2006). We then couple this phenomenological cluster model with areaction-diffusion equation, so as to have a discrete stochastic modelfor calcium dynamics.  The model we propose describes the transitionregimes between isolated release and steadily propagating waves as theIP3 concentration is increased.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Physical Society  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
calcio  
dc.subject
señales  
dc.subject
modelado  
dc.subject.classification
Otras Ciencias Físicas  
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Ciencias Físicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Stochastic fire-diffuse-fire model with realistic cluster dynamics  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-09-02T12:17:29Z  
dc.identifier.eissn
1539-3755  
dc.journal.volume
82  
dc.journal.number
3  
dc.journal.pagination
319101-3191012  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Calabrese, Ana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Columbia University; Estados Unidos  
dc.description.fil
Fil: Fraiman, Daniel. Universidad de San Andrés. Departamento de Matemáticas y Ciencias; Argentina  
dc.description.fil
Fil: Zysman, Daniel. University of Ottawa; Canadá  
dc.description.fil
Fil: Ponce Dawson, Silvina Martha. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Physical Review E: Statistical, Nonlinear and Soft Matter Physics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/pre/abstract/10.1103/PhysRevE.82.031910  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1103/PhysRevE.82.031910