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dc.contributor.author
del Sole, Maria Jose
dc.contributor.author
Schaiquevich, Paula Susana
dc.contributor.author
Aba, Marcelo Alfredo
dc.contributor.author
Lanusse, Carlos Edmundo
dc.contributor.author
Moreno Torrejon, Laura
dc.date.available
2024-09-02T12:33:21Z
dc.date.issued
2012
dc.identifier.citation
Effect of melatonin on prednisolone eye disposition In cats; Association for Research in Vision and Ophthalmology Annual Meeting; Fort Laudardale; Estados Unidos; 2012; 1-2
dc.identifier.issn
0146-0404
dc.identifier.uri
http://hdl.handle.net/11336/243393
dc.description.abstract
Purpose: To characterize prednisolone (PRED) ocular and systemic pharmacokinetics in cats after oral administration and to study the effect of concomitant administration of melatonin (MEL) on PRED disposition. Methods: Six (6) castrated young physically and ophthalmologically healthy male European Short Hair cats were orally administrated with a single dose (10 mg) of PRED or a single dose of PRED (10 mg) and MEL (3 mg) in tablet. In anesthetized cats 2 mL of blood and 450 µL of aqueous humor (AH) were obtained from preplaced cephalic antebrachial intravenous catheters and from one eye by direct puncture, respectively, at: 0.25, 0.5, 1, 1.5, 2, 3, 4 and 5 h after administration. Plasma and AH samples were assayed for PRED by HPLC. A two-compartment model was used to simultaneously fit PRED plasma and aqueous concentration vs. time data using ADAPT 5. The estimated pharmacokinetic (PK) parameters included the absorption rate constant (ka), elimination rate constant from the central compartment (kc), intercompartment rate constants between plasma and aqueous humor (kpa), apparent volume of distribution of the central compartment (Vc/F). PK parameters were compared between groups (PRED vs. PRED+MEL) by means of Wilcoxon matched pairs test (p<0.05). Results: The model adequately fitted the data and the estimated median (interval) PK parameters are shown in Table 1. No significant difference was observed in the PK parameters when comparing between groups of treatments (p>0.05). Conclusion: These results indicated that MEL does not modify PRED systemic or ocular disposition in cats when both are administrated simultaneously. A possible synergic pharmacological effect may be account for different mechanisms of action, but not for pharmacokinetic synergism and will be further studied.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Association for Research in Vision and Ophthalmology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CORTICOSTEROIDS
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MELATONIN
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ANTIOXIDANTS
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Effect of melatonin on prednisolone eye disposition In cats
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-08-12T15:17:56Z
dc.journal.volume
53
dc.journal.number
14
dc.journal.pagination
1-2
dc.journal.pais
Estados Unidos
dc.journal.ciudad
St. Louis
dc.description.fil
Fil: del Sole, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Endocrinología; Argentina
dc.description.fil
Fil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Unidad de Farmacocinética Clínica. Laboratorio Farmacia; Argentina
dc.description.fil
Fil: Aba, Marcelo Alfredo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Endocrinología; Argentina
dc.description.fil
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://iovs.arvojournals.org/article.aspx?articleid=2349280&resultClick=1
dc.conicet.rol
Autor
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Autor
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Autor
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Autor
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Autor
dc.coverage
Internacional
dc.type.subtype
Reunión
dc.description.nombreEvento
Association for Research in Vision and Ophthalmology Annual Meeting
dc.date.evento
2012-05-06
dc.description.ciudadEvento
Fort Laudardale
dc.description.paisEvento
Estados Unidos
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
Association for Research in Vision and Ophthalmology
dc.source.revista
Investigative Ophthalmology & Visual Science
dc.date.eventoHasta
2012-05-10
dc.type
Reunión
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