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dc.contributor.author
Fridman, Osvaldo
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dc.contributor.author
Corró, Lucrecia
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dc.contributor.author
Herkovits, Jorge
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dc.date.available
2024-08-30T11:48:31Z
dc.date.issued
2004-06
dc.identifier.citation
Fridman, Osvaldo; Corró, Lucrecia; Herkovits, Jorge; Estradiol uptake, toxicity, metabolism, and adverse effects on cadmium-treated amphibian embryos; U.S. Department of Health and Human Sciences. Public Health and Science; Environmental Health Perspectives; 112; 8; 6-2004; 862-866
dc.identifier.issn
0091-6765
dc.identifier.uri
http://hdl.handle.net/11336/243330
dc.description.abstract
The exposure of Bufo arenarum embryos to 25 µmol/L 17β-estradiol (E2) resulted in 100% lethality within 48 hr, whereas 10 µmol//L E2 was the no observed effect concentration value for shortterm chronic (7 days) exposure. The toxicity profile curves show that lethal effects were proportional to the E2 concentration and the time of exposure. The E2 uptake resulted in 20.1 ng E2/mg embryo at 8 hr posttreatment, but 67.3% of this value was achieved during the first 30 min of incubation with this estrogen. Regarding metabolism, the embryos synthesize estrone (E1) from E2 by means of 17β-hydroxysteroid dehydrogenase. Simultaneous treatments of Bufo arenarum embryos with 1 mg/L Cd2+ and 0.1, 1, or 10 µmol/L E2 enhanced the lethality exerted by cadmium in 76.7, 80, and 83.3% of embryos, respectively. The results indicate that estrogenic endocrine disruptors could have an adverse effect on amphibian embryos and enhance the toxic effect of Cd on amphibian embryos. This study points to the possibility of using the AMPHITOX test as a screening method for potential endocrine disruption as well as the combined effects of chemical mixtures.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
U.S. Department of Health and Human Sciences. Public Health and Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
estradiol toxicity
dc.subject
cadmium
dc.subject
endocrine disruption
dc.subject
amphibian embryo
dc.subject.classification
Otros Tópicos Biológicos
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Estradiol uptake, toxicity, metabolism, and adverse effects on cadmium-treated amphibian embryos
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-30T11:27:33Z
dc.journal.volume
112
dc.journal.number
8
dc.journal.pagination
862-866
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Fridman, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Pro Salud y Medio Ambiente; Argentina
dc.description.fil
Fil: Corró, Lucrecia. Fundación Pro Salud y Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Herkovits, Jorge. Fundación Pro Salud y Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Environmental Health Perspectives
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ehp.niehs.nih.gov/doi/10.1289/ehp.6647?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1289/ehp.6647
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