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dc.contributor.author
Rodrigues Barbosa, Mayara
dc.contributor.author
Lopes Costa, Ellyda Fernanda
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Gomes Coimbra, Daniel
dc.contributor.author
Braga Cavalcante Pinto, Vinícius
dc.contributor.author
Leite Goes Gitaí, Daniel
dc.contributor.author
Duzzioni, Marcelo
dc.contributor.author
Crespo, Manuel Tomas
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dc.contributor.author
Golombek, Diego Andrés
dc.contributor.author
Chiesa, Juan José
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dc.contributor.author
Agostino, Patricia Verónica
dc.contributor.author
Gomes de Andrade, Tiago
dc.date.available
2024-08-28T15:12:22Z
dc.date.issued
2024-08
dc.identifier.citation
Rodrigues Barbosa, Mayara; Lopes Costa, Ellyda Fernanda; Gomes Coimbra, Daniel; Braga Cavalcante Pinto, Vinícius; Leite Goes Gitaí, Daniel; et al.; Transitional photoperiod induces a mania‐like behavior in male mice; Wiley Blackwell Publishing, Inc; European Journal of Neuroscience; 8-2024; 1-15
dc.identifier.issn
0953-816X
dc.identifier.uri
http://hdl.handle.net/11336/243263
dc.description.abstract
This study aimed to investigate the behavioral responses and circadianrhythms of mice to both rapid and gradual increases in photoperiod, mimickingthe transition from winter to summer, which is associated with a heightenedprevalence of hospitalizations for mania and suicidal behavior.Behavioral tests were performed in C57BL/6 male mice exposed to a transitionalphotoperiod, from short to long durations. To determine if circadianrhythms are affected, we measured spontaneous locomotor activity and bodytemperature. Mice exhibited heightened exploratory and risk-taking behaviorscompared with equatorial and static long (16:8 h of light–dark cycle for severaldays) groups. These behaviors were prevented by lithium. Spontaneous locomotoractivity and body temperature rhythms persisted and were effectivelysynchronized; however, the relative amplitude of activity and interdaily stabilitywere diminished. Additionally, the animals displayed increased activityduring the light phase. Photoperiodic transition modulates behavior and circadianrhythms, mirroring certain features observed in bipolar disorder patients.This study introduces an animal model for investigating mania-like behaviorinduced by photoperiodic changes, offering potential insights for suicide preventionstrategies and the management of mood disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
bipolar disorder
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circadian rhythm
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lithium
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risk-taking
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seasonal variation
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suicide
dc.subject.classification
Biología
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Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Transitional photoperiod induces a mania‐like behavior in male mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-26T14:56:47Z
dc.journal.pagination
1-15
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Rodrigues Barbosa, Mayara. Universidade Federal de Alagoas; Brasil
dc.description.fil
Fil: Lopes Costa, Ellyda Fernanda. Universidade Federal de Alagoas; Brasil
dc.description.fil
Fil: Gomes Coimbra, Daniel. Universidade Federal de Alagoas; Brasil
dc.description.fil
Fil: Braga Cavalcante Pinto, Vinícius. Universidade Federal de Alagoas; Brasil
dc.description.fil
Fil: Leite Goes Gitaí, Daniel. Universidade Federal de Alagoas; Brasil
dc.description.fil
Fil: Duzzioni, Marcelo. Universidade Federal de Alagoas; Brasil
dc.description.fil
Fil: Crespo, Manuel Tomas. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
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Fil: Golombek, Diego Andrés. Universidad de San Andrés; Argentina. Universidad Nacional de Quilmes; Argentina
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Fil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Agostino, Patricia Verónica. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.description.fil
Fil: Gomes de Andrade, Tiago. Universidade Federal de Alagoas; Brasil
dc.journal.title
European Journal of Neuroscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/ejn.16498
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ejn.16498
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