Artículo
Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
Gomez Rosso, Leonardo Adrián
; Meroño, Tomás
; Giunta, Gustavo Ariel
; Boero, Laura Estela; Schreier, Laura Ester; Cuniberti, Luis Alberto
; Brites, Fernando Daniel
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Fecha de publicación:
03/2012
Editorial:
Elsevier Science
Revista:
Clinica Chimica Acta
ISSN:
0009-8981
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background and aims: Several studies have been carried out to characterize the different alterations associated with hypertriglyceridemia (HTG) and to identify this dyslipemia as an independent risk factor for cardiovascular disease (CVD). HTG is frequently, but not always, associated with insulin resistance (IR). The present study was aimed to evaluate if the alterations observed in biomarkers of CVD were similar in HTG states independently of IR. Methods: HTG was defined as triglycerides ≥1.69 mmol/l and IR as HOMA-IR ≥3.1. HTG-IR patients (n= 15) were compared with HTG subjects without IR (WIR) (n= 15) and with normotriglyceridemic (NTG)-WIR individuals (n= 30). Results: Both HTG groups shared the increment in VLDL-C and non-HDL-C, HDL enrichment in triglycerides and depletion in phospholipids, the decrease in adiponectin concentration, and the increase in CETP activity. HDL-C and VCAM-1 levels were altered only in HTG-IR patients in comparison with the other groups, while oxidized LDL was only higher in HTG-IR than the control group. Multiple regression analysis identified triglycerides as the independent predictor of HDL-C, CETP activity and oxidized LDL levels. Conclusion: The increase in triglycerides is the major determinant factor of the atherogenic modifications observed, while IR would be an amplifier factor.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Gomez Rosso, Leonardo Adrián; Meroño, Tomás; Giunta, Gustavo Ariel; Boero, Laura Estela; Schreier, Laura Ester; et al.; Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance; Elsevier Science; Clinica Chimica Acta; 413; 5-6; 3-2012; 620-624
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