Artículo
Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
Chamorro Cañon, Juan David
; Luna, Maria Alejandra
; Sabini, Maria Carola
; Molina, Patricia Gabriela
; Correa, Nestor Mariano
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Fecha de publicación:
20/05/2024
Editorial:
American Chemical Society
Revista:
Journal of Physical Chemistry B
ISSN:
1520-6106
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
5-Fluorouracil (5-FU) is an antineoplastic agent known for its low bioavailability and limited cellular penetration, often resulting in adverse effects on healthy cells. Thus, finding vehicles that enhance bioavailability, enable controlled release, and mitigate adverse effects is crucial. The study focuses on encapsulating 5-FU within soy lecithin vesicles (SLVs) and assessing its impact on the carrier´s properties and functionality. Results show that incorporating 5-FU does not affect SLVs´ size or polydispersity, even post-lyophilization. Liberation of 5-FU from SLVs requires system disruption rather than spontaneous release, with an encapsulation efficiency of approximately 43% determined using Square Wave Voltammetry. Cytotoxicity assays on colorectal cancer cells reveal SLV-based delivery´s significant efficacy, surpassing free drug solution effects with 45% cell viability after 72 hours versus 73% viability. The research addresses 5-FU´s limited bioavailability by creating a biocompatible nanocarrier for efficient drug delivery, highlighting SLVs as promising for targeted cancer therapy due to sustained antiproliferative effects and improved cellular uptake. The study underscores the importance of tailored drug delivery systems in enhancing therapeutic outcomes and suggests SLV/5-FU formulations as a potential advancement in cancer treatment strategies.
Palabras clave:
Soy Lecithin Vesicles
,
5-Fluorouracil
,
Electrochemistry
,
Drug delivery
Archivos asociados
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Identificadores
Colecciones
Articulos (IDAS)
Articulos de INSTITUTO PARA EL DESARROLLO AGROINDUSTRIAL Y DE LA SALUD
Articulos de INSTITUTO PARA EL DESARROLLO AGROINDUSTRIAL Y DE LA SALUD
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Chamorro Cañon, Juan David; Luna, Maria Alejandra; Sabini, Maria Carola; Molina, Patricia Gabriela; Correa, Nestor Mariano; Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles; American Chemical Society; Journal of Physical Chemistry B; 128; 22; 20-5-2024; 5427-5436
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