Artículo
Optimized Electrophoretic Deposition of Chitosan/Mesoporous Glass Nanoparticles with Gentamicin on Titanium Implants: Enhancing Hemocompatibility and Antibacterial Activity
Uicich, Florencia Carolina; Merlo, Julieta
; Redersdorff, Ingrid Emelin
; Herrera Seitz, Karina
; Pastore, Juan Ignacio
; Ballarre, Josefina
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Fecha de publicación:
05/07/2024
Editorial:
American Chemical Society
Revista:
ACS Applied Bio Materials
ISSN:
2576-6422
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Titanium-based implants have long been studied and used for applications in bone tissue engineering, thanks to their outstanding mechanical properties and appropriate biocompatibility. However, many implants struggle with osseointegration and attachment and can be vulnerable to the development of infections. In this work, we have developed a composite coating via electrophoretic deposition, which is both bioactive and antibacterial. Mesoporous bioactive glass particles with gentamicin were electrophoretically deposited onto a titanium substrate. In order to validate the hypothesis that the quantity of particles in the coatings is sufficiently high and uniform in each deposition process, an easy-to-use image processing algorithm was designed to minimize human dependence and ensure reproducible results. The addition of loaded mesoporous particles did not affect the good adhesion of the coating to the substrate although roughness was clearly enhanced. After 7 days of immersion, the composite coatings were almost dissolved and released, but phosphate-related compounds started to nucleate at the surface. With a simple and low-cost technique like electrophoretic deposition, and optimized stir and suspension times, we were able to synthesize a hemocompatible coating that significantly improves the antibacterial activity when compared to the bare substrate for both Gram-positive and Gram-negative bacteria.
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Articulos(ICYTE)
Articulos de INSTITUTO DE INVESTIGACIONES CIENTIFICAS Y TECNOLOGICAS EN ELECTRONICA
Articulos de INSTITUTO DE INVESTIGACIONES CIENTIFICAS Y TECNOLOGICAS EN ELECTRONICA
Articulos(IIB)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
Uicich, Florencia Carolina; Merlo, Julieta; Redersdorff, Ingrid Emelin; Herrera Seitz, Karina; Pastore, Juan Ignacio; et al.; Optimized Electrophoretic Deposition of Chitosan/Mesoporous Glass Nanoparticles with Gentamicin on Titanium Implants: Enhancing Hemocompatibility and Antibacterial Activity; American Chemical Society; ACS Applied Bio Materials; 7; 7; 5-7-2024; 4642-4653
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