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dc.contributor.author
Eöry, M. L.  
dc.contributor.author
Zanuzzi, Carolina Natalia  
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Fuentealba, Nadia Analia  
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Sguazza, Guillermo Hernán  
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Gimeno, Eduardo Juan  
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Galosi, Cecilia Monica  
dc.contributor.author
Barbeito, Claudio Gustavo  
dc.date.available
2017-09-14T19:11:51Z  
dc.date.issued
2013-02-04  
dc.identifier.citation
Eöry, M. L.; Zanuzzi, Carolina Natalia; Fuentealba, Nadia Analia; Sguazza, Guillermo Hernán; Gimeno, Eduardo Juan; et al.; Effects of different anesthetics in the murine model of EHV-1 infection; American College of Veterinary Pathologists; Veterinary Pathology; 50; 5; 4-2-2013; 849-856  
dc.identifier.issn
0300-9858  
dc.identifier.uri
http://hdl.handle.net/11336/24283  
dc.description.abstract
Mice are commonly used as an experimental model to investigate the Equid herpesvirus 1 (EHV-1) infection. This model easily reproduces the disease, and the clinical signs are more or less similar to those observed in the horse, the natural host. During natural infection, the acute course of respiratory infection is mandatory for the development of adaptive immune response. Since interactions between EHV-1 and anesthetics are possible, the study investigated whether the early events of murine pulmonary immune response could be affected by different anesthetics. Therefore, mice were experimentally infected with a unique EHV-1 strain under the effects of ether, ketamine/xylazine, or isoflurane. Clinical signs and histopathological lesions in the lungs were described, and the cell death and proliferation rates of sham-inoculated or infected animals were quantified using immunohistochemistry. Clinical signs were more severe in animals anesthetized with ether. Qualitative differences in the recruited inflammatory cells were observed following application of anesthesia. The level of infection between the infected groups was not statistically significant. However, lungs from ketamine/xylazine-anesthetized animals showed the highest cell death rates, whereas those from isoflurane-anesthetized animals showed the highest proliferation rates. It has been emphasized that anesthetics alone or their interactions with EHV-1 modify the response against the infection. An appropriate selection of the anesthetic during experimental studies is relevant to minimize wrong conclusions.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American College of Veterinary Pathologists  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Anesthetics  
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Apoptosis  
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Equid Herpesvirus 1  
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Immunohistochemistry  
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Mice  
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Proliferation  
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Ciencias Veterinarias  
dc.subject.classification
Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Effects of different anesthetics in the murine model of EHV-1 infection  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-08-23T20:36:49Z  
dc.journal.volume
50  
dc.journal.number
5  
dc.journal.pagination
849-856  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Eöry, M. L.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina  
dc.description.fil
Fil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Fuentealba, Nadia Analia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Sguazza, Guillermo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina  
dc.description.fil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Galosi, Cecilia Monica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Veterinary Pathology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0300985813476062  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0300985813476062