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dc.contributor.author
Twu, Olivia
dc.contributor.author
de Miguel, Natalia
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dc.contributor.author
Lustig, Gil
dc.contributor.author
Stevens, Grant C.
dc.contributor.author
Vashisht, Ajay A.
dc.contributor.author
Wohlschlegel, James A.
dc.contributor.author
Johnson, Patricia J.
dc.date.available
2017-09-14T18:17:41Z
dc.date.issued
2013-07-11
dc.identifier.citation
Twu, Olivia; de Miguel, Natalia; Lustig, Gil; Stevens, Grant C.; Vashisht, Ajay A.; et al.; Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host: Parasite Interactions; Public Library of Science; Plos Pathogens; 9; 7; 11-7-2013; 1-14
dc.identifier.issn
1553-7366
dc.identifier.uri
http://hdl.handle.net/11336/24262
dc.description.abstract
Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogential tract where it remains extracellular and adheres to epithelial cells. Infections range from asymptomatic to highly inflammatory, depending on the host and the parasite strain. Here, we use a combination of methodologies including cell fractionation, immunofluorescence and electron microscopy, RNA, proteomic and cytokine analyses and cell adherence assays to examine pathogenic properties of T. vaginalis. We have found that T.vaginalis produces and secretes microvesicles with physical and biochemical properties similar to mammalian exosomes. The parasite-derived exosomes are characterized by the presence of RNA and core, conserved exosomal proteins as well as parasite-specific proteins. We demonstrate that T. vaginalis exosomes fuse with and deliver their contents to host cells and modulate host cell immune responses. Moreover, exosomes from highly adherent parasite strains increase the adherence of poorly adherent parasites to vaginal and prostate epithelial cells. In contrast, exosomes from poorly adherent strains had no measurable effect on parasite adherence. Exosomes from parasite strains that preferentially bind prostate cells increased binding of parasites to these cells relative to vaginal cells. In addition to establishing that parasite exosomes act to modulate host∶parasite interactions, these studies are the first to reveal a potential role for exosomes in promoting parasite∶parasite communication and host cell colonization.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Exosomes
dc.subject
Parasite
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Pathogenesis
dc.subject
Trichomonas
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host: Parasite Interactions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-14T13:53:08Z
dc.journal.volume
9
dc.journal.number
7
dc.journal.pagination
1-14
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Twu, Olivia. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: de Miguel, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Lustig, Gil. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Stevens, Grant C.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Vashisht, Ajay A.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Wohlschlegel, James A.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Johnson, Patricia J.. University of California at Los Angeles; Estados Unidos
dc.journal.title
Plos Pathogens
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.ppat.1003482
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003482
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