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dc.contributor.author
Ons, Sheila
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dc.contributor.author
Rotllant, David
dc.contributor.author
Marín Blasco, Ignacio J.
dc.contributor.author
Armario, Antonio
dc.date.available
2024-08-14T10:29:48Z
dc.date.issued
2010-06
dc.identifier.citation
Ons, Sheila; Rotllant, David; Marín Blasco, Ignacio J.; Armario, Antonio; Immediate‐early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c‐fos mRNA to adaptation; Wiley Blackwell Publishing, Inc; European Journal of Neuroscience; 31; 11; 6-2010; 2043-2052
dc.identifier.issn
0953-816X
dc.identifier.uri
http://hdl.handle.net/11336/242450
dc.description.abstract
Stress exposure resulted in brain induction of immediate-early genes (IEGs), considered as markers of neuronal activation. Upon repeated exposure to the same stressor, reduction of IEG response (adaptation) has been often observed, but there are important discrepancies in literature that may be in part related to the particular IEG and methodology used. We studied the differential pattern of adaptation of the IEGs c-fos and arc (activity-regulated cytoskeleton-associated protein) after repeated exposure to a severe stressor: immobilization on wooden boards (IMO). Rats repeatedly exposed to IMO showed reduced c-fos mRNA levels in response to acute IMO in most brain areas studied: the medial prefrontal cortex (mPFC), lateral septum (LS), medial amygdala (MeA), paraventricular nucleus of the hypothalamus (PVN) and locus coeruleus. In contrast, the number of neurons showing Fos-like immunoreactivity was only reduced in the MeA and the various subregions of the PVN. IMO-induced increases in arc gene expression were restricted to telencephalic regions and reduced by repeated IMO only in the mPFC. Double-labelling in the LS of IMO-exposed rats revealed that arc was expressed in only one-third of Fos+ neurons, suggesting two populations of Fos+ neurons. These data suggest that c-fos mRNA levels are more affected by repeated IMO than corresponding protein, and that arc gene expression does not reflect adaptation in most brain regions, which may be related to its constitutive expression. Therefore, the choice of a particular IEG and the method of measurement are important for proper interpretation of the impact of chronic repeated stress on brain activation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADAPTATION
dc.subject
CHRONIC STRESS
dc.subject
PARAVENTRICULAR HYPOTHALAMIC NUCLEUS
dc.subject
RAT
dc.subject.classification
Zoología, Ornitología, Entomología, Etología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Immediate‐early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c‐fos mRNA to adaptation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-12T14:01:34Z
dc.journal.volume
31
dc.journal.number
11
dc.journal.pagination
2043-2052
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Rotllant, David. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Marín Blasco, Ignacio J.. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Armario, Antonio. Universitat Autònoma de Barcelona; España
dc.journal.title
European Journal of Neuroscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1460-9568.2010.07242.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1460-9568.2010.07242.x
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