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dc.contributor.author
Granero, Gladys Ester
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dc.contributor.author
Amidon, Gordon L.
dc.date.available
2024-08-13T14:44:11Z
dc.date.issued
2008-02
dc.identifier.citation
Granero, Gladys Ester; Amidon, Gordon L.; Possibility of enterohepatic recycling of ketoprofen in dogs; Elsevier Science; International Journal Of Pharmaceutics; 349; 1-2; 2-2008; 166-171
dc.identifier.issn
0378-5173
dc.identifier.uri
http://hdl.handle.net/11336/242414
dc.description.abstract
Ketoprofen is mainly cleared by glucuronidation. The rate of glucuronidation of this compound has been demonstrated to be greater in dog than in human liver microsomes. Dog is the most common secondary nonprimate species used in drug metabolism studies in the pharmaceutical industry. Therefore, this study was undertaken to provide valuable information to pharmaceutical companies using dog as a model species for pharmacokinetic analyses when differences in glucuronidation occur across species for therapeutic drugs known to be extensively glucuronidated. The pharmacokinetics of ketoprofen was investigated after intravenous (0.27, 0.57 and 1.10 mg/kg) and oral administration of ketoprofen (∼10 mg/100 ml) of the racemate in dogs. Serial blood samples were collected at timed intervals for 7 and 24 h following intravenous and oral administration of the dose, respectively, and concentrations in plasma were determined by a sensitive and specific HPLC method. By comparing the AUC0−∞ following oral and intravenous administrations, ketoprofen bioavailability was ∼100%. A possibility of enterohepatic cycling of ketoprofen in dogs was proposed because of multiple peak phenomenon in the concentration?time profiles after intravenous and oral dosing was observed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
KETOPROFEN
dc.subject
ENTEROHEPATIC CIRCULATION
dc.subject
PHARMACOKINETICS
dc.subject
ABSORPTION
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Possibility of enterohepatic recycling of ketoprofen in dogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-13T13:50:08Z
dc.journal.volume
349
dc.journal.number
1-2
dc.journal.pagination
166-171
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Granero, Gladys Ester. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.description.fil
Fil: Amidon, Gordon L.. University of Michigan; Estados Unidos
dc.journal.title
International Journal Of Pharmaceutics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378517307006655
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijpharm.2007.08.005
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