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dc.contributor.author
Flood, Diana E. K.
dc.contributor.author
Fernandino, Juan Ignacio
dc.contributor.author
Langlois, Valerie
dc.date.available
2017-09-14T17:04:36Z
dc.date.issued
2013-10-01
dc.identifier.citation
Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie; Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 2-14
dc.identifier.issn
0016-6480
dc.identifier.uri
http://hdl.handle.net/11336/24236
dc.description.abstract
Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Thyroid Hormone
dc.subject
Androgen
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Hypothalamus-Pituitary-Thyroid/Gonadal Axis
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Steroidogenesis
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Promoter Analysis
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Sex-Determining-Genes
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-06T17:16:36Z
dc.journal.volume
192
dc.journal.pagination
2-14
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Flood, Diana E. K.. Royal Military College of Canada; Canadá. Queens University; Canadá
dc.description.fil
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
dc.description.fil
Fil: Langlois, Valerie. Royal Military College of Canada; Canadá
dc.journal.title
General and Comparative Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ygcen.2013.02.038
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013001159
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