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dc.contributor.author
Kruse, Maria Sol  
dc.contributor.author
Suarez, Lucas Gabriel  
dc.contributor.author
Coirini, Hector  
dc.date.available
2017-09-14T15:31:11Z  
dc.date.issued
2017-02  
dc.identifier.citation
Kruse, Maria Sol; Suarez, Lucas Gabriel; Coirini, Hector; Regulation of the expression of LXR in rat hypothalamic and hippocampal explants; Elsevier Ireland; Neuroscience Letters; 639; 2-2017; 53-58  
dc.identifier.issn
0304-3940  
dc.identifier.uri
http://hdl.handle.net/11336/24229  
dc.description.abstract
Liver X receptors (LXR) are important transcription factors involved in the regulation of carbohydrate and lipid metabolism and are expressed in different brain areas. Recently we described that LXR expression in the hypothalamus is sensitive to serum levels of lipids and carbohydrates. Here, we further characterized the effects of glucose, insulin, cholesterol and cholic acid on the expression of LXRα and LXRβ in hypothalamus and hippocampus explants as in vitro models. The LXR activation products, GLUT2 and ABCA1, were also analyzed by Western blot. Glucose had different effects in the hypothalamus compared to the hippocampus. In the hypothalamus, increases in glucose concentrations decreased LXRβ expression while in the hippocampus increased both receptor subtypes levels. In contrast, insulin treatment decreased LXRβ in the hypothalamus while having no effects on the hippocampus. Cholic acid and cholesterol increased only LXRα expression in the hypothalamus whereas no effects on the hippocampus were detected. The newly expressed LXR receptors may be functional active since the level of the LXR activation product ABCA1 was also increased. Changes in GLUT2 expression was observed only when LXRβ levels were increased. Altogether these data show that LXR are sensitive to glucose, insulin and lipids in vitro, as well as in vivo as we previously showed, suggesting an involvement of LXR in central metabolic pathways and control of energy homeostasis.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Abca1  
dc.subject
Cholesterol  
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Cholic Acid  
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Glut2  
dc.subject.classification
Bioquímica y Biología Molecular  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Regulation of the expression of LXR in rat hypothalamic and hippocampal explants  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-09-06T19:36:26Z  
dc.identifier.eissn
1872-7972  
dc.journal.volume
639  
dc.journal.pagination
53-58  
dc.journal.pais
Irlanda  
dc.journal.ciudad
Limerick  
dc.description.fil
Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Suarez, Lucas Gabriel. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina  
dc.journal.title
Neuroscience Letters  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0304394016310138  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neulet.2016.12.065  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/28038938