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dc.contributor.author
Mestorino, N.
dc.contributor.author
Formentini, Enrique Antonio
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dc.contributor.author
Lucas, Mariana Florencia
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dc.contributor.author
Fernandez, C.
dc.contributor.author
Modamio, P.
dc.contributor.author
Mariño Hernández, E.
dc.contributor.author
Errecalde, J. O.
dc.date.available
2024-08-12T10:49:51Z
dc.date.issued
2008-02
dc.identifier.citation
Mestorino, N.; Formentini, Enrique Antonio; Lucas, Mariana Florencia; Fernandez, C.; Modamio, P.; et al.; Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide; Springer; Veterinary Research Communications; 32; 1; 2-2008; 21-33
dc.identifier.issn
0165-7380
dc.identifier.uri
http://hdl.handle.net/11336/242222
dc.description.abstract
A comparative pharmacokinetic study was conducted to determine the order and the rate of absorption of triclabendazole (TCBZ) in cattle and sheep. A commercial suspension of TCBZ (Biofasiolex, Biogénesis S.A., Argentina) was administered at a dose rate of 10 mg/kg by the oral route to six Holstein female calves and six Corriedale female sheep. The plasma concentration profiles of the metabolites triclabendazole sulfoxide (TCBZ-SO) and triclabendazole sulfone (TCBZ-SO(2)) were analysed by means of the non-compartmental method. The order of the absorption process of the active metabolite, TCBZ-SO, was determined by construction of curves of cumulative absorbed fraction of the drug by means of the Wagner-Nelson method. The appearance of TCBZ-SO in plasma of cattle and sheep resembles the entry of a constant quantity of drug into the organism per unit time. This is explained by the reservoir effect of the rumen, which acts as a biological slow-release system for TCBZ-SO and its precursor TCBZ to the posterior digestive tract where they are absorbed. The plasma concentration profiles of TCBZ-SO in both species were well described by a one-compartment open model with zero-order process of absorption and first-order process of elimination. The values of AUC(0-infinity) and C(max) of TCBZ-SO did not differ between species, while other kinetic parameters except for lambda(z) had higher values in calves than in sheep. In the case of TCBZ-SO(2), t(max) was the only parameter that did not differ between species, while other kinetic parameters except for lambda(z) had higher values in calves than in sheep.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pharmacokinetic
dc.subject
Triclabendazole
dc.subject
Cattle
dc.subject
Sheep
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-07T11:12:44Z
dc.journal.volume
32
dc.journal.number
1
dc.journal.pagination
21-33
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Mestorino, N.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina
dc.description.fil
Fil: Formentini, Enrique Antonio. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Lucas, Mariana Florencia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Fernandez, C.. Universidad de Barcelona; España
dc.description.fil
Fil: Modamio, P.. Universidad de Barcelona; España
dc.description.fil
Fil: Mariño Hernández, E.. Universidad de Barcelona; España
dc.description.fil
Fil: Errecalde, J. O.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina
dc.journal.title
Veterinary Research Communications
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs11259-007-9000-3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11259-007-9000-3
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