Artículo
Opposite effects of protein kinase C beta1 (PKCβ1) and PKCε in the metastatic potential of a breast cancer murine model
Grossoni, Valeria Carla
; Todaro, Laura Beatriz
; Kazanietz, Marcelo Gabriel; Bal, Elisa Dora
; Urtreger, Alejandro Jorge
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Fecha de publicación:
01/2009
Editorial:
Springer
Revista:
Breast Cancer Research and Treatment
ISSN:
0167-6806
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In this paper we investigated whether protein kinase C (PKC) b1 and PKCe, members of the classical and novel PKC family respectively, induce phenotypic alterations that could be associated with tumor progression and metastatic dissemination in a murine model of breast cancer. Stable overexpression of PKCb1 in LM3 cells altered their ability to proliferate, adhere, and survive, and impaired their tumorigenicity and metastatic capacity. Moreover, PKCb1 induced the re-expression of fibronectin, an extracellular matrix glycoprotein which loss has been associated with the acquisition of a transformed phenotype in different cell models, and exerted an important inhibition on proteases production, effects that probably impact on LM3 invasiveness and dissemination. Conversely, PKCe overexpression enhanced LM3 survival, anchorage-independent growth, and caused a significant increase in spontaneous lung metastasis. Our results suggest PKCb1 functions as an inhibitory protein for tumor growth and metastasis dissemination whereas PKCe drives metastatic dissemination without affecting primary tumor growth.
Palabras clave:
PKCb1
,
PKCe
,
METASTASIS DISSEMINATION
,
TUMOR GROWTH
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Grossoni, Valeria Carla; Todaro, Laura Beatriz; Kazanietz, Marcelo Gabriel; Bal, Elisa Dora; Urtreger, Alejandro Jorge; Opposite effects of protein kinase C beta1 (PKCβ1) and PKCε in the metastatic potential of a breast cancer murine model; Springer; Breast Cancer Research and Treatment; 118; 3; 1-2009; 469-480
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