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dc.contributor.author
Fernandez, Elmer Andres

dc.contributor.author
Valtuille, Rodolfo

dc.contributor.author
Willshaw, Peter
dc.contributor.author
Balzarini, Monica Graciela

dc.date.available
2024-08-09T10:56:11Z
dc.date.issued
2008-04
dc.identifier.citation
Fernandez, Elmer Andres; Valtuille, Rodolfo; Willshaw, Peter; Balzarini, Monica Graciela; Partial Least Squares Regression: A Valuable Method for Modeling Molecular Behavior in Hemodialysis; Springer; Annals Of Biomedical Engineering; 36; 7; 4-2008; 1305-1313
dc.identifier.issn
0090-6964
dc.identifier.uri
http://hdl.handle.net/11336/242165
dc.description.abstract
The aim of this work was to use the Partial Least Squares Regression (PLS) technique to fit simple models for the interpretation of an underlying complex process. In this study, the technique was used to build a statistical model for molecular kinetic data obtained from hemodialyzed patients. By using PLS we derived statistical linear models for the prediction of the equilibrated urea concentration. Models with an average relative prediction error (RPE) of less than 0.05% were achieved. The model predictive accuracy was evaluated in a cross-center study yielding an RPE < 3%. The chosen model was robust to variations such as sampling extraction time demonstrating a high capacity for modeling kinetics. It also was found to be useful for bed-side monitoring. Finally, the PLS technique allowed identification of the most important co-variables in the model and of those patients with outlier patterns in their molecular dynamics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer

dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
KINETIC MODELING
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EQUILIBRATED UREA
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HEMODIALYSIS ADEQUACY
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STATISTICAL MODELING
dc.subject.classification
Biotecnología relacionada con la Salud

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Biotecnología de la Salud

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CIENCIAS MÉDICAS Y DE LA SALUD

dc.title
Partial Least Squares Regression: A Valuable Method for Modeling Molecular Behavior in Hemodialysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-08T15:51:31Z
dc.journal.volume
36
dc.journal.number
7
dc.journal.pagination
1305-1313
dc.journal.pais
Alemania

dc.journal.ciudad
Berlín
dc.description.fil
Fil: Fernandez, Elmer Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba; Argentina
dc.description.fil
Fil: Valtuille, Rodolfo. No especifíca;
dc.description.fil
Fil: Willshaw, Peter. Swansea University; Reino Unido
dc.description.fil
Fil: Balzarini, Monica Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba; Argentina
dc.journal.title
Annals Of Biomedical Engineering

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10439-008-9492-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10439-008-9492-1
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