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dc.contributor.author
Sanchez, Julieta Maria
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dc.contributor.author
López Laguna, Hèctor
dc.contributor.author
Parladé, Eloi
dc.contributor.author
Somma, Angela Di
dc.contributor.author
Livieri, Andrea L.
dc.contributor.author
Álamo, Patricia
dc.contributor.author
Mangues, Ramón
dc.contributor.author
Unzueta, Ugutz
dc.contributor.author
Villaverde, Antonio
dc.contributor.author
Vázquez, Esther
dc.date.available
2024-08-08T13:36:58Z
dc.date.issued
2024-03
dc.identifier.citation
Sanchez, Julieta Maria; López Laguna, Hèctor; Parladé, Eloi; Somma, Angela Di; Livieri, Andrea L.; et al.; Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids; Wiley; Advanced Science; 11; 21; 3-2024; 1-11
dc.identifier.issn
2198-3844
dc.identifier.uri
http://hdl.handle.net/11336/242116
dc.description.abstract
Developing time-sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory granules from the mammalian endocrine system it has generated non-toxic microscale amyloid materials through the coordination between divalent metals and poly-histidine stretches. Like their natural counterparts that keep the functionalities of the assembled protein, those synthetic structures release biologically active proteins during a slow self-disintegration process occurring in vitro and upon in vivo administration. Being these granules formed by a single pure protein species and therefore, chemically homogenous, they act as highly promising time-sustained drug delivery systems. Despite their enormous clinical potential, the nature of the clustering process and the quality of the released protein have been so far neglected issues. By using diverse polypeptide species and their protein-only oligomeric nanoscale versions as convenient models, a conformational rearrangement and a stabilization of the building blocks during their transit through the secretory granules, being the released material structurally distinguishable from the original source is proved here. This fact indicates a dynamic nature of secretory amyloids that act as conformational arrangers rather than as plain, inert protein-recruiting/protein-releasing granular depots.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Cell-targeting
dc.subject
Drug delivery
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Microparticles
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Nanoparticles
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Recombinant proteins
dc.subject
Secretory granules
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-05T13:21:47Z
dc.journal.volume
11
dc.journal.number
21
dc.journal.pagination
1-11
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Sanchez, Julieta Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: López Laguna, Hèctor. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Parladé, Eloi. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Somma, Angela Di. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Livieri, Andrea L.. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Álamo, Patricia. Hospital de la Santa Creu I Sant Pau; España
dc.description.fil
Fil: Mangues, Ramón. Hospital de la Santa Creu I Sant Pau; España
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Fil: Unzueta, Ugutz. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Villaverde, Antonio. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Vázquez, Esther. Universitat Autònoma de Barcelona; España
dc.journal.title
Advanced Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/advs.202309427
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/advs.202309427
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