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dc.contributor.author
Bittencourt, Jackson
dc.contributor.author
Cobe, Maria Esther
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dc.date.available
2024-08-08T13:23:11Z
dc.date.issued
2008-08
dc.identifier.citation
Bittencourt, Jackson; Cobe, Maria Esther; Anatomy, function and regulation of neuropeptide EI (NEI); Elsevier Science Inc.; Peptides; 29; 8; 8-2008; 1441-1450
dc.identifier.issn
0196-9781
dc.identifier.uri
http://hdl.handle.net/11336/242112
dc.description.abstract
This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc.
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)
dc.subject
ANATOMY
dc.subject
PHYSIOLOGY
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BEHAVIOUR
dc.subject
HORMONES
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REGULATION: CNS
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IMMUNOREACTIVITY
dc.subject
RATS
dc.subject
NEUROTRANSMITERS
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Anatomy, function and regulation of neuropeptide EI (NEI)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-07T11:18:07Z
dc.journal.volume
29
dc.journal.number
8
dc.journal.pagination
1441-1450
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Bittencourt, Jackson. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Cobe, Maria Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Medicina. Cátedra de Bacteriología y Virología Médicas; Argentina
dc.journal.title
Peptides
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0196978108001332
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.peptides.2008.03.012
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