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dc.contributor.author
Cano, Pilar
dc.contributor.author
Cardinali, Daniel Pedro
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dc.contributor.author
Jimenez, Vanessa
dc.contributor.author
Alvarez, Maria P.
dc.contributor.author
Cutrera, Rodolfo Angel
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dc.contributor.author
Esquifino, Ana I.
dc.date.available
2024-08-08T11:45:21Z
dc.date.issued
2005-12
dc.identifier.citation
Cano, Pilar; Cardinali, Daniel Pedro; Jimenez, Vanessa; Alvarez, Maria P.; Cutrera, Rodolfo Angel; et al.; Effect of Interferon-γ Treatment on 24-Hour Variations in Plasma ACTH, Growth Hormone, Prolactin, Luteinizing Hormone and Follicle-Stimulating Hormone of Male Rats; Karger; NeuroImmunoModulation; 12; 3; 12-2005; 146-151
dc.identifier.issn
1021-7401
dc.identifier.uri
http://hdl.handle.net/11336/242088
dc.description.abstract
Interferon-gamma (IFN-gamma) is a cytokine produced by T helper cells on antigenic challenge that may affect the release of several pituitary hormones. However, in vitro or in vivo studies have yielded disparate results with stimulatory, inhibitory or absent effects of IFN on pituitary hormone release. One of the reasons for these discrepancies could be that hormone changes were commonly assessed at a single time point in the day-night cycle. In this study we measured the circadian pattern of plasma ACTH, growth hormone (GH), prolactin, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) at 6 different time points within a 24-hour cycle in adult male Wistar rats. METHODS: Groups of 6-8 rats kept under light from 08:00 to 20:00 h daily received 5 daily injections intraperitoneally of human IFN-gamma (10(5) IU/kg body weight) or saline at 08:30 h. Plasma ACTH, GH, prolactin, LH and FSH levels were measured by a homologous specific double antibody RIA. RESULTS: A factorial ANOVA for main effects indicated a significant 43% increase of circulating prolactin in IFN-gamma-treated rats. Time of day changes were significant for the five hormones examined and these diurnal variations became altered by IFN-gamma administration, with a phase advance of ACTH peak, a suppression of the rest phase peak of GH, the appearance of a second peak of prolactin at an early phase of daily photoperiod, and the blunting of the 24-hour variations of plasma FSH. CONCLUSION: The data point out an effect of IFN-gamma on the mechanisms responsible for the circadian organization of pituitary hormone release.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
INTERFERON GAMMA
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Effect of Interferon-γ Treatment on 24-Hour Variations in Plasma ACTH, Growth Hormone, Prolactin, Luteinizing Hormone and Follicle-Stimulating Hormone of Male Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-05T14:06:32Z
dc.journal.volume
12
dc.journal.number
3
dc.journal.pagination
146-151
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Cano, Pilar. No especifíca;
dc.description.fil
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Jimenez, Vanessa. No especifíca;
dc.description.fil
Fil: Alvarez, Maria P.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Cutrera, Rodolfo Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
dc.description.fil
Fil: Esquifino, Ana I.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
dc.journal.title
NeuroImmunoModulation
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000084846
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://karger.com/nim/article-abstract/12/3/146/229108/Effect-of-Interferon-Treatment-on-24-Hour?redirectedFrom=fulltext
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