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Lifschitz, Adrian Luis  
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Kolar, Lusija  
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Sallovitz, Juan Manuel  
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Suarez, Víctor Humberto  
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Cerkvenik Flajs, Vesna  
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Pogacnik, Milan  
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Kozuh Erzen, Nevenka  
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Lanusse, Carlos Edmundo  
dc.date.available
2024-08-08T10:18:06Z  
dc.date.issued
2007  
dc.identifier.citation
Chemical stability of veterinary drugs residues in feces: adverse environmental impact?; XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental; Ciudad Autónoma de Buenos Aires; Argentina; 2007; 66-66  
dc.identifier.uri
http://hdl.handle.net/11336/242059  
dc.description.abstract
The macrocyclic lactones (ML) are broad-spectrum antiparasitic drugs excreted in large concentrations as unchanged parent drugs in feces. The current work evaluated the comparative chemical stability of different ML drugs in feces from treated sheep and cattle exposed to environmental field conditions. Fecal depositions from sheep and cattle subcutaneously treated with different ML were kept in the field during different time periods (between 6 and 180 days). Drug fecal concentrations were measured by HPLC. The ML drugs showed a sustained chemical stability. Long persistence of fecal drug residues were observed in the feces exposed to field conditions. Although a rapid decrease in ML fecal concentrations were observed over the first 14 days (cattle) and 32 days (sheep) post-deposition, a slow chemical degradation accounting for the long persistence of the active parent molecules in the environment was registered. Doramectin was the ML compound recovered at the highest residual concentration in feces from both animal species. Even after 100 days of field exposure, doramectin concentrations were 308 (sheep) and 425 (cattle) ng/g dry faeces. The potential adverse effects of the fecal residual concentrations against nontarget organisms are under evaluation in an Argentina-Slovenia binational collaborative project.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Sociedad Argentina de Farmacología Experimental  
dc.rights
info:eu-repo/semantics/openAccess  
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Chemical stability  
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Faeces  
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Macrocyclic lactones  
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Ciencias Veterinarias  
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Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Chemical stability of veterinary drugs residues in feces: adverse environmental impact?  
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info:eu-repo/semantics/publishedVersion  
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info:eu-repo/semantics/conferenceObject  
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info:ar-repo/semantics/documento de conferencia  
dc.date.updated
2024-08-05T13:25:16Z  
dc.journal.pagination
66-66  
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Argentina  
dc.journal.ciudad
Ciudad Autónoma de Buenos Aires  
dc.description.fil
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina  
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Fil: Kolar, Lusija. University of Ljubljana. Veterinary Faculty; Eslovenia  
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Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina  
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Fil: Suarez, Víctor Humberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina  
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Fil: Cerkvenik Flajs, Vesna. University of Ljubljana. Veterinary Faculty; Eslovenia  
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Fil: Pogacnik, Milan. University of Ljubljana. Veterinary Faculty; Eslovenia  
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Fil: Kozuh Erzen, Nevenka. University of Ljubljana. Veterinary Faculty; Eslovenia  
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Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina  
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info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/wp-content/uploads/2021/07/ACTA_2007.pdf  
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dc.type.subtype
Reunión  
dc.description.nombreEvento
XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental  
dc.date.evento
2007-11-27  
dc.description.ciudadEvento
Ciudad Autónoma de Buenos Aires  
dc.description.paisEvento
Argentina  
dc.type.publicacion
Book  
dc.description.institucionOrganizadora
Asociación Argentina de Farmacología Experimental  
dc.source.libro
Libro de resúmenes de la XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental  
dc.date.eventoHasta
2007-11-30  
dc.type
Reunión