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Breda, Susana Andrea
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González, Carlos
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Confalonieri, Alejandra
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Sanchez Bruni, Sergio Fabian
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Manzo, Ruben Hilario
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Olivera, María Eugenia
dc.date.available
2024-08-08T10:11:05Z
dc.date.issued
2009
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Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse; LXI Reunion Anual de Sociedad Argentina de Farmacología Experimental; Rosario; Argentina; 2009; 28-28
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http://hdl.handle.net/11336/242057
dc.description.abstract
The aim of this study was to assess the plasma pharmacokinetics, tissue distribution and efficacy of a formulation ciprofloxacin (CIP)-Aluminum complex based (CIP-Al) in comparison with a conventional CIP formulation. For this study 96 Balb-C mice were divided in two groups and treated as follows: Group I received orally a single dose of CIP 5 mg/kg. Animals of Group II were identically treated but with CIP-AL formulation. Samples of blood, lung, intestine and kidney, were taken over 12 h post-treatment, and frozen until analysis by HPLC. The experimental efficacy study was based in an experimental Salmonella infection model in mice. Mice were divided into 3 groups: Control (distilled water treatment), CIP and CIP-Al. After 5 days of treatment survival was recorded. The plasma pharmacokinetics study outcomes revealed similar AUC values for CIP and CIP-Al. However, CIP concentration levels were statistically (P< 0.05) higher in lung, intestine and kidney after CIP-Al administration than those obtained for CIP conventional formulation group after 1h post treatment. The higher tissue concentrations of CIP-Al may have contributed to the observed efficacy trend where survived 33% of mice treated compared with the conventional CIP formulation assayed (0%). This fact would be related to the improved aqueous compatibility of CIP after aluminum complexation. We found that CIP-Al is at least as effective as CIP and exhibited advantageous pharmacokinetic and dispositional properties. It may become a valuable asset based on its formulation versatility due to higher solubility.
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application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Farmacología Experimental
dc.rights
info:eu-repo/semantics/openAccess
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CIPROFLOXACIN-ALUMINIUM
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PHARMACOKINETICS
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MICE
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TISSUE DISTRIBUTION
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse
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info:eu-repo/semantics/publishedVersion
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info:eu-repo/semantics/conferenceObject
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info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-08-05T13:26:00Z
dc.journal.pagination
28-28
dc.journal.pais
Argentina
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Ciudad Autónoma de Buenos Aires
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Fil: Breda, Susana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
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Fil: González, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
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Fil: Confalonieri, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
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Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
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Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
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Fil: Olivera, María Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
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info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/wp-content/uploads/2021/07/ACTA_2009.pdf
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dc.coverage
Internacional
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Reunión
dc.description.nombreEvento
LXI Reunion Anual de Sociedad Argentina de Farmacología Experimental
dc.date.evento
2009-11-24
dc.description.ciudadEvento
Rosario
dc.description.paisEvento
Argentina
dc.type.publicacion
Book
dc.description.institucionOrganizadora
Sociedad Argentina de Farmacología Experimental
dc.source.libro
Libro de resúmenes de la LXI Reunión Anual de Sociedad Argentina de Farmacología Experimental
dc.date.eventoHasta
2009-11-26
dc.type
Reunión
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