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dc.contributor.author
Peichoto, María Elisa
dc.contributor.author
Teibler, Pamela
dc.contributor.author
Mackessy, S.
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Leiva, Laura Cristina Ana
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Acosta, Ofelia Cristina
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Gonçalves, L. R. C.
dc.contributor.author
Tanaka Azevedo, A.
dc.contributor.author
Santoro, M.
dc.date.available
2024-08-07T15:23:50Z
dc.date.issued
2007-01
dc.identifier.citation
Peichoto, María Elisa; Teibler, Pamela; Mackessy, S.; Leiva, Laura Cristina Ana; Acosta, Ofelia Cristina; et al.; Purification and characterization of patagonfibrase, a metalloproteinase showing α-fibrinogenolytic and hemorrhagic activities, from Philodryas patagoniensis snake venom; Elsevier Science; Biochimica et Biophysica Acta - General Subjects; 1770; 5; 1-2007; 810-819
dc.identifier.issn
0304-4165
dc.identifier.uri
http://hdl.handle.net/11336/242028
dc.description.abstract
Venoms of Colubridae snakes are a rich source of novel compounds, which may have applications in medicine and biochemistry. In the present study, we describe the purification and characterization of a metalloproteinase (patagonfibrase), the first protein to be isolated fromPhilodryas patagoniensis (Colubridae) snake venom. Patagonfibrase is a single-chain protein, showing a molecular mass of 53,224 Da and an acidic isoelectric point (5.8). It hydrolyzed selectively the Aá-chain of fibrinogen and when incubated with fibrinogen or plasma, the thrombin clotting time was prolonged. Prominent hemorrhage developed in mouse skin after intradermal injection of patagonfibrase. When administered into mouse gastrocnemius muscle, it induced local hemorrhage and necrosis, and systemic bleeding in lungs. Patagonfibrase showed proteolytic activity toward azocasein, which was enhanced by Ca 2+ and inhibited by Zn2+, cysteine, dithiothreitol and Na2EDTA. Patagonfibrase impaired platelet aggregation induced by collagen and ADP. Thus, patagonfibrase may play a key role in the pathogenesis of disturbances that occur in P. patagoniensis envenomation, and may be used as a biological tool to explore many facets of hemostasis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COLUBRID SNAKE VENOM
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FIBRINOGEN
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HEMORRHAGE
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METALLOPROTEINASE
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COAGULATION
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PLATELETS
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Purification and characterization of patagonfibrase, a metalloproteinase showing α-fibrinogenolytic and hemorrhagic activities, from Philodryas patagoniensis snake venom
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-05T13:39:17Z
dc.journal.volume
1770
dc.journal.number
5
dc.journal.pagination
810-819
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Peichoto, María Elisa. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
dc.description.fil
Fil: Teibler, Pamela. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Mackessy, S.. Univeristy Of Northem Colorado. School Of Biological Sciences; Estados Unidos
dc.description.fil
Fil: Leiva, Laura Cristina Ana. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina
dc.description.fil
Fil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
dc.description.fil
Fil: Gonçalves, L. R. C.. Governo Do Estado de Sao Paulo. Secretaria Da Saude. Instituto Butantan. Laboratorio de Fisiopatologia; Brasil
dc.description.fil
Fil: Tanaka Azevedo, A.. Governo Do Estado de Sao Paulo. Secretaria Da Saude. Instituto Butantan. Laboratorio de Fisiopatologia; Brasil
dc.description.fil
Fil: Santoro, M.. Governo Do Estado de Sao Paulo. Secretaria Da Saude. Instituto Butantan. Laboratorio de Fisiopatologia; Brasil
dc.journal.title
Biochimica et Biophysica Acta - General Subjects
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304416506003850
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbagen.2006.12.014
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