Artículo
Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A
Szebenyi, Györgyi; Bollati, Flavia Andrea
; Bisbal, Mariano
; Sheridan, Shelley; Faas, Laura; Wray, Robin; Haferkamp, Scott; Nguyen, Sapril; Caceres, Alfredo Oscar
; Brady, Scott T.
Fecha de publicación:
10/2005
Editorial:
Cell Press
Revista:
Current Biology
ISSN:
0960-9822
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Activity-prompted dendritic remodeling leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within hours. However, dendrite growth continues for days and requires extension and stabilization of the cytoskeleton in nascent processes. In addition to binding microtubules, microtubule-associated proteins (MAPs) associate with the actin cytoskeleton, anchor ion channels and signaling complexes, and modulate synaptic growth. MAP2 is predominantly dendritic. MAP1B is at postsynaptic densities (PSD) and modulates ion channel activity, in addition to affecting axon growth. Less is known about MAP1A, but it is also enriched in dendrites at input locations, including PSDs where MAP1A associates with channel complexes and the calcium sensor caldendrin. MAP1A rescued hearing loss in tubby mice. Here we show that MAP1A becomes enriched in dendrites concurrently with dendritic branching and synapse formation in the developing brain; that synaptic activity is required for establishing mature MAP1A expression levels; and that MAP1A expression is required for activity-dependent growth, branching, and stabilization of the dendritic arbor.
Palabras clave:
NEURONAL POLARITY
,
DENDRITOGENESIS
,
SIGNALING MECHANISMS
,
MAP1A
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Szebenyi, Györgyi; Bollati, Flavia Andrea; Bisbal, Mariano; Sheridan, Shelley; Faas, Laura; et al.; Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A; Cell Press; Current Biology; 15; 20; 10-2005; 1820-1826
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