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dc.contributor.author
Babb, Paul L.  
dc.contributor.author
McIntosh, Annick M.  
dc.contributor.author
Fernandez Duque, Eduardo  
dc.contributor.author
Schurr, Theodore  
dc.date.available
2015-10-08T18:58:02Z  
dc.date.issued
2013-10-08  
dc.identifier.citation
Babb, Paul L.; McIntosh, Annick M.; Fernandez Duque, Eduardo; Schurr, Theodore; Prolactin receptor gene diversity in Azara's owl monkeys (Aotus azarai) and humans (Homo sapiens) suggests a non-neutral evolutionary history among primates; Springer/Plenum Publishers; International Journal of Primatology; 35; 1; 8-10-2013; 129-155  
dc.identifier.issn
0164-0291  
dc.identifier.uri
http://hdl.handle.net/11336/2419  
dc.description.abstract
Although paternal care is rare in mammals, males of several primate taxa exhibit high degrees of this behavior. Studies of many species of vertebrates found a positive correlation between prolactin (PRL) levels and paternal care. Studies of maternal care in knockoutmice indicate that the prolactin receptor (PRLR) plays a critical role in the neural regulation of parental care. To understand better the extent of PRLR genetic variation within primates, we characterized intraspecific coding variation in Azara?s owl monkeys (Aotus azarai) fromnorthern Argentina, a species with intensive paternal care. We then examined PRLR variation in 1088 humans (Homo sapiens) from the 1000 Genomes Project. Lastly, we assessed interspecific variation in PRLR in 4 different Aotus spp. and 12 phylogenetically (and behaviorally) disparate primate taxa. Our analyses revealed that the coding region of PRLR exhibits significant variation in all species of primates, with nonsynonymous amino acid substitutions being enriched in the intracellular domain, a region responsible for activation of downstream targets in thePRL pathway. In addition, several species exhibit entire codon deletions in this region. These results suggest a non-neutral evolutionary history of the PRLR locus within different primate lineages, and further imply that the translated PRLR protein has undergone considerable change throughout primate evolution. Such changes may be driven by selection for different behaviors and physiologies resulting from modulations of the pleiotropic prolactin pathway. Yet, the genetic variants in PRLR among primate taxa do not discretely cluster with species-level differences in paternal care behaviors, signifying that other mechanisms must be involved in the regulation of paternal care in primates.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer/Plenum Publishers  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BEHAVIORAL GENETICS  
dc.subject
NIGHT MONKEY  
dc.subject
PATERNAL CARE  
dc.subject
PLATYRRHINI  
dc.subject
PRLR  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Prolactin receptor gene diversity in Azara's owl monkeys (Aotus azarai) and humans (Homo sapiens) suggests a non-neutral evolutionary history among primates  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-03-30 10:35:44.97925-03  
dc.journal.volume
35  
dc.journal.number
1  
dc.journal.pagination
129-155  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: Babb, Paul L.. University of Pennsylvania; Estados Unidos de América;  
dc.description.fil
Fil: McIntosh, Annick M.. University Of Yale; Estados Unidos de América;  
dc.description.fil
Fil: Fernandez Duque, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Centro de Ecologia Aplicada del Litoral (i); Argentina  
dc.description.fil
Fil: Schurr, Theodore. University of Pennsylvania; Estados Unidos de América;  
dc.journal.title
International Journal of Primatology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10764-013-9721-9  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10764-013-9721-9