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dc.contributor.author
Mengatto, Luciano Nicolas
dc.contributor.author
Pesoa, Juan Ignacio
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Velazquez, Natalia Soledad
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Luna, Julio Alberto
dc.date.available
2017-09-13T19:53:24Z
dc.date.issued
2016-09
dc.identifier.citation
Mengatto, Luciano Nicolas; Pesoa, Juan Ignacio; Velazquez, Natalia Soledad; Luna, Julio Alberto; Application of simultaneous multiple response optimization in the preparation of thermosensitive chitosan/glycerophosphate hydrogels; Springer; Iranian Polymer Journal; 25; 11; 9-2016; 897-906
dc.identifier.issn
1026-1265
dc.identifier.uri
http://hdl.handle.net/11336/24186
dc.description.abstract
The parameters affecting the sol/gel transition of chitosan-based thermogelling systems, their final proper-ties and structure have been reported. Nevertheless, equa-tions that define this relationship specific for a particular case have not been developed. The aim of this study was to develop these equations for a general formulation without drugs, so they could be used in the preparation of different drug delivery systems. First, a factorial design was built to evaluate the main factors affecting the pH of a gel-forming solution, gelling time at ambient temperature and 37.5 °C and residual mass after exposure to a buffer solution. The analyzed independent factors were: chitosan concentration, β-glycerophosphate concentration, mixing temperature and mixing time. Mixing time was the only factor whose effect on the responses was not significant; the other three factors were considered for the optimization study. Then, a central composite design based on response surface methodology was carried out to develop statistical models which describe the relationship between active independent factors and the studied responses. The optimized gel was prepared and characterized. FTIR experiments showed that hydrogen bonds and electrostatic attraction were the main types of interactions following sol-to-gel transition. The most important finding of this investigation was that the resulting equations could be used to prepare gel-forming solutions with the desired pH, gelling time and residualmass. The significance of these equations was considered in their potential use to design hydrogels intended for con-trolled drug delivery.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chitosan
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Thermosensitive Hydrogel
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Statistical Optimizatoin
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Β-Glycerophosphate
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Biopolymer
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Compuestos
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Application of simultaneous multiple response optimization in the preparation of thermosensitive chitosan/glycerophosphate hydrogels
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-04T15:09:02Z
dc.journal.volume
25
dc.journal.number
11
dc.journal.pagination
897-906
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Pesoa, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Velazquez, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.journal.title
Iranian Polymer Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s13726-016-0475-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs13726-016-0475-z
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