Artículo
A novel human adenovirus hexon protein of species D found in an AIDS patient
Ferreyra, Leonardo Jesús; Giordano, Miguel Oscar; Martinez, Laura; Isa, M. Beatriz; Barril, Patricia Angelica
; Masachessi, Gisela
; Grutadauria, Sergio Luis; Pavan, Jorge Victorio; Nates, Silvia Viviana
Fecha de publicación:
11/2009
Editorial:
Springer Wien
Revista:
Archives of Virology
ISSN:
0304-8608
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
To date, human adenoviruses are classified into 53 types (types 1-51 and types 53 and 54), which have been grouped into six species named A through F, and the recently identified type 52 has been proposed as member of a new species, G. Type classification is based on type-specific epitopes within loop 1 (L1) and loop 2 (L2) of the hexon protein, which contain seven hypervariable regions that are responsible for type specificity. In this paper, we present the characterization of an adenovirus strain isolated from a male AIDS patient in Cordoba, Argentina. This strain was found to be a member of species D by genomic Sma I restriction analysis. Sequencing of the L1 and L2 regions of the hexon gene and immunological characterization by virus neutralization revealed this hexon to be unique and distinct from the previously identified hexons of types within species D. A seroepidemiologic study in the human population of Cordoba showed that this strain was not endemic in the local human population.
Palabras clave:
ADENOVIRUS
,
EXON
,
LOOP
,
SPECIES
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Ferreyra, Leonardo Jesús; Giordano, Miguel Oscar; Martinez, Laura; Isa, M. Beatriz; Barril, Patricia Angelica; et al.; A novel human adenovirus hexon protein of species D found in an AIDS patient; Springer Wien; Archives of Virology; 155; 1; 11-2009; 27-35
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