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dc.contributor.author
Olmedo, Daniel Gustavo
dc.contributor.author
Tasat, Deborah Ruth
dc.contributor.author
Guglielmotti, Maria Beatriz
dc.contributor.author
Cabrini, Rómulo L.
dc.date.available
2024-08-06T11:10:54Z
dc.date.issued
2005-03
dc.identifier.citation
Olmedo, Daniel Gustavo; Tasat, Deborah Ruth; Guglielmotti, Maria Beatriz; Cabrini, Rómulo L.; Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: An experimental study in rats; Wiley-liss, div John Wiley & Sons Inc.; Journal of Biomedical Materials Research Part A; 73A; 2; 3-2005; 142-149
dc.identifier.issn
1549-3296
dc.identifier.uri
http://hdl.handle.net/11336/241809
dc.description.abstract
Metallic implants of titanium are used therapeutically in biomedicine because of its excellent biocompatibility. However, no metal or alloy is completely inert. We have previously shown that titanium oxide (TiO(2)) is transported in blood by phagocytic monocytes and deposited in organs such as liver, spleen, and lung 6 months after intraperitoneal injection (ip). Furthermore, it is well known that exposure to metal traces alters the cellular redox status. Thus, the aim of the present study was to determine the presence of titanium in target organs after chronic exposure, assess the potential structural alterations, and evaluate the oxidative metabolism of alveolar macrophages (AM) in the lung. Rats were ip injected with 1.60 g/100 g body wt of TiO(2) in saline solution. Organs (liver, spleen, lung) were processed for histological evaluation. Reactive oxygen species (ROS) in AM obtained by bronchoalveolar lavage (BAL) were evaluated using the nitroblue tetrazolium test and quantitative evaluation by digital image analysis. The histological analysis of organs revealed the presence of titanium in the parenchyma of these organs with no associated tissue damage. Although in lung alveolar macrophages TiO(2) induced a significant rise in ROS generation, it failed to cause tissue alteration. This finding may be attributed to an adaptive response.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Titanium dioxide
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lungs
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macrophages
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oxidative metablism
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rats
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: An experimental study in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-05T13:41:24Z
dc.journal.volume
73A
dc.journal.number
2
dc.journal.pagination
142-149
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Tasat, Deborah Ruth. Universidad Nacional de San Martín; Argentina
dc.description.fil
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Cabrini, Rómulo L.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina
dc.journal.title
Journal of Biomedical Materials Research Part A
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.30230
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jbm.a.30230
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