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dc.contributor.author
Malanga, Gabriela Fabiana
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dc.contributor.author
Ostera, Juan Manuel
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dc.contributor.author
Puntarulo, Susana Angela
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dc.date.available
2024-08-05T15:26:52Z
dc.date.issued
2015
dc.identifier.citation
Malanga, Gabriela Fabiana; Ostera, Juan Manuel; Puntarulo, Susana Angela; Assessment of Oxidative Balance in the Lipo- and Hydro-philic Cellular Environment in Biological Systems; Nova Science Publishers; 1; 2015; 43-60
dc.identifier.isbn
978-1-63321-886-4
dc.identifier.uri
http://hdl.handle.net/11336/241745
dc.description.abstract
Over the last decade, Electron Paramagnetic Resonance (EPR) technology has been successfully applied to detect free radicals in order to establish oxidative stress conditions. Since a variety of stable products are formed during the oxidation of lipids, several assays have been developed over the years in order to evaluate lipid peroxidation. EPR spectroscopy has shown the capacity to detect, in the presence of exogenous traps, the presence of lipid radicals (LR•) formed during peroxidation, by yielding unique and stable compounds. On the other hand, the one-electron oxidation of AH- produces ascorbyl radical (A•) which is easily detectable by EPR, even at room-temperature in aqueous solution. The A• free radical has a relatively long lifetime compared to other species, such as hydroxyl radical, peroxyl, alkoxyl, and LR• and has been proposed as a marker of oxidative stress, either in vitro or in vivo, in numerous systems, such as plasma. All biological systems contain many antioxidants, including both water-soluble compounds (such as AH- and glutathione), and lipid-soluble antioxidants, such as - tocopherol (-T). In this chapter, the most widely used indexes of oxidative balance in biological systems will be briefly summarized. Moreover, special mention will be made about the application of the A•/AH- and LR•/-T ratios to situations of oxidative stress. The goal of this work is to discuss the possibility of detecting the actual state of lipid- and water-soluble fractions of a biological system, providing an early and simple diagnosis of stressing conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nova Science Publishers
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
OXIDATIVE INDEXES
dc.subject
LIPOPHILIC MEDIUM
dc.subject
HYDROPHILIC MEDIUM
dc.subject
ASCORBIL RADICAL
dc.subject
LIPID SOLUBLE RADICALS
dc.subject
ANTIOXIDANTS
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Assessment of Oxidative Balance in the Lipo- and Hydro-philic Cellular Environment in Biological Systems
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2024-08-02T13:14:19Z
dc.journal.volume
1
dc.journal.pagination
43-60
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Malanga, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Ostera, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Puntarulo, Susana Angela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://novapublishers.com/shop/reactive-oxygen-species-lipid-peroxidation-and-protein-oxidation/
dc.conicet.paginas
280
dc.source.titulo
Reactive Oxygen Species, Lipid Peroxidation and Protein Oxidation
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