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dc.contributor.author
Demarchi, Dario
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dc.contributor.author
Mosher, M.J.
dc.contributor.author
Crawford, Michael H.
dc.date.available
2024-08-05T12:08:08Z
dc.date.issued
2005-12
dc.identifier.citation
Demarchi, Dario; Mosher, M.J.; Crawford, Michael H.; Apolipoproteins (apoproteins) and LPL variation in Mennonite populations of Kansas and Nebraska; Wiley-liss, div John Wiley & Sons Inc.; American Journal of Human Biology; 17; 5; 12-2005; 593-600
dc.identifier.issn
1042-0533
dc.identifier.uri
http://hdl.handle.net/11336/241694
dc.description.abstract
Apoproteins (also known as apolipoproteins) have been studied extensively because of their role in lipid transport, association between specific genotypes and elevated serum lipid levels, and increased risk of heart disease. There is considerable genetic variation in the geographic distributions of these markers, with a north-south cline of the APOE*4 allele observed in Europe by Lucotte et al. ([1997] Hum Biol 69:253–262). This study compares the frequencies of seven APO (APOA1 75 bp, APOA1 þ83 bp, APOB Ins/Del, APOB XbaI, APOC3 SstI, and APOE) and LPL loci in Mennonite populations from Kansas and Nebraska. In total, 277 individuals were sampled from Goessel, Meridian, Garden View, and Lone Tree in 2002–2004. In addition, DNA samples that were collected in 1981 from Henderson, Nebraska, were genotyped for the seven APO and LPL loci. Of the seven APO and LPL loci tested, only one locus, APOB XbaI, departed significantly from Hardy-Weinberg equilibrium, with an unexpected excess of observed heterozygotes. The frequencies of the several APO loci are unique among the Mennonites, separating them from other European populations. A bidimensional scaling representation of Reynold’s coancestry distances based on allelic frequencies of the seven APO and LPL markers in five Mennonite congregations fails to represent schematically the known patterns of fission. It is unclear whether the observed patterns are due to selection operating on these loci or whether genetic drift, small populations sizes, or a lack of statistical power of these biallelic loci distort the observed genetic relationship among congregations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Apolipoproteins
dc.subject
Kansas
dc.subject
Nebraska
dc.subject.classification
Antropología, Etnología
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dc.subject.classification
Sociología
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dc.subject.classification
CIENCIAS SOCIALES
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dc.title
Apolipoproteins (apoproteins) and LPL variation in Mennonite populations of Kansas and Nebraska
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-06-04T14:41:18Z
dc.journal.volume
17
dc.journal.number
5
dc.journal.pagination
593-600
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Demarchi, Dario. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Museo de Antropología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; Argentina
dc.description.fil
Fil: Mosher, M.J.. University of North Carolina; Estados Unidos
dc.description.fil
Fil: Crawford, Michael H.. University of Kansas; Estados Unidos
dc.journal.title
American Journal of Human Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajhb.20425
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/ajhb.20425
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