Artículo
Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
Gomez, María Lorena
; Williams, Roberto Juan Jose
; Montejano, Hernan Alfredo
; Previtali, Carlos Mario
![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
03/2012
Editorial:
Budapest University of Technology and Economics
Revista:
Express Polymer Letters
ISSN:
1788-618X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The influence of the ionic character of a specific drug on its release rate from a hydrogel based on 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) is analyzed. The hydrogel was synthesized by photopolymerization employing visible light, safranine O (Saf), as sensitizer, and a silsesquioxane functionalized with amine and methacrylate groups (SFMA), as co-initiator and crosslinker. Safranine O (Saf) was employed as a model of a cationic drug and the anionic form of resorufin (Rf) as a model of an anionic drug. Saf exhibited a larger affinity with functional groups of the hydrogel than that of Rf. This produced a lower loading and a faster release rate of Rf with respect to Saf. Besides, the release rate of Rf followed a Fickian behavior while that of Saf exhibited a non-Fickian behavior. By hydrolyzing the hydrogel at pH = 13, amide groups supplied by AAm were irreversibly converted into carboxylic acid groups. Higher loadings and slower release rates of Saf from the hydrolyzed hydrogels were observed, making them particularly suitable for the slow drug-delivery of cationic drugs.
Palabras clave:
Polymer gels
,
Hydrogels
,
Drug release
,
Hydroxyethylmethacrylate
,
Acrylamide
Archivos asociados
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Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
Gomez, María Lorena; Williams, Roberto Juan Jose; Montejano, Hernan Alfredo; Previtali, Carlos Mario; Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization; Budapest University of Technology and Economics; Express Polymer Letters; 6; 3; 3-2012; 189-197
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