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dc.contributor.author
Campanini Salinas, Javier
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Opitz Ríos, Catherine
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Sagredo Mella, John A.
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Contreras Sanchez, Danilo
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Giménez, Matías
dc.contributor.author
Páez, Paula Andrea
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dc.contributor.author
Tarifa, Maria Clara
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Rubio, Nataly D.
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Medina, Daniel A.
dc.date.available
2024-08-05T10:21:31Z
dc.date.issued
2024-07
dc.identifier.citation
Campanini Salinas, Javier; Opitz Ríos, Catherine; Sagredo Mella, John A.; Contreras Sanchez, Danilo; Giménez, Matías; et al.; Antimicrobial Resistance Elements in Coastal Water of Llanquihue Lake, Chile; MDPI; Antibiotics; 13; 7; 7-2024; 1-14
dc.identifier.issn
2079-6382
dc.identifier.uri
http://hdl.handle.net/11336/241635
dc.description.abstract
Antimicrobial resistance has been stated to be a global health problem. In Chile, the use of antibiotics should be declared by medical prescription, but it is unknown what happens to the drugs once the treatment ends. Among the possibilities for their disposal are the trash or the drain; regardless of which scenario arises, antibiotics could accumulate in the environment, stimulating the emergence of antimicrobial resistance mechanisms and their transfer between microorganisms. Unfortunately, sometimes wastewater ends up in bodies of water, due to the dragging of elements by rain, or by the presence of illegal water discharges. In this work, shotgun metagenomics was used to elucidate the functional and microbial composition of biohazard elements in the bay of Puerto Varas City, Chile. As expected, a high diversity of microorganisms was found, including bacterial elements described as human or animal pathogens. Also, a diverse repertory of antimicrobial resistant genes (ARGs) was detected, which confers mainly resistance to macrolides, beta-lactams, and tetracyclines, consistent with the families of antibiotics most used in Chile. Similar ARGs were identified in DNA mobile elements. In addition, we tested the antimicrobial susceptibility in 14 bacterial strains isolated from Llanquihue Lake. This is the first report of the presence of genomic elements that could constitute a health problem, considering the importance of the interconnection between environmental, animal, and human health, a concept known as One Health.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANTIMICROBIAL RESISTANCE
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METAGENOMICS
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DNA MOBILE ELEMENTS
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Biotecnología Medioambiental
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Biotecnología del Medio Ambiente
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INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Antimicrobial Resistance Elements in Coastal Water of Llanquihue Lake, Chile
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-02T12:43:25Z
dc.journal.volume
13
dc.journal.number
7
dc.journal.pagination
1-14
dc.journal.pais
Suiza
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dc.description.fil
Fil: Campanini Salinas, Javier. Universidad San Sebastian.; Chile
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Fil: Opitz Ríos, Catherine. Universidad San Sebastian.; Chile
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Fil: Sagredo Mella, John A.. Universidad San Sebastian.; Chile
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Fil: Contreras Sanchez, Danilo. Universidad San Sebastian.; Chile
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Fil: Giménez, Matías. Institut Pasteur Montevideo; Uruguay
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Fil: Páez, Paula Andrea. Universidad Nacional de Rio Negro. Centro de Investigaciones y Transferencia de Rio Negro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Rio Negro; Argentina
dc.description.fil
Fil: Tarifa, Maria Clara. Universidad Nacional de Rio Negro. Centro de Investigaciones y Transferencia de Rio Negro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Rio Negro; Argentina
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Fil: Rubio, Nataly D.. Universidad San Sebastian.; Chile
dc.description.fil
Fil: Medina, Daniel A.. Universidad San Sebastian.; Chile
dc.journal.title
Antibiotics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/13/7/679
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/antibiotics13070679
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