Mostrar el registro sencillo del ítem

dc.contributor.author
Rojas, Bruno Ezequiel  
dc.contributor.author
Iglesias, Alberto Alvaro  
dc.date.available
2024-08-02T12:30:44Z  
dc.date.issued
2023-07  
dc.identifier.citation
Rojas, Bruno Ezequiel; Iglesias, Alberto Alvaro; Integrating multiple regulations on enzyme activity: the case of phospho enol pyruvate carboxykinases; Oxford University Press; AoB PLANTS; 15; 4; 7-2023; 1-11  
dc.identifier.issn
2041-2851  
dc.identifier.uri
http://hdl.handle.net/11336/241595  
dc.description.abstract
Data on protein post-translational modifications (PTMs) increased exponentially in the last years due to the refinement of mass spectrometry techniques and the development of databases to store and share datasets. Nevertheless, these data per se do not create comprehensive biochemical knowledge. Complementary studies on protein biochemistry are necessary to fully understand the function of these PTMs at the molecular level and beyond, for example, designing rational metabolic engineering strategies to improve crops. Phosphoenolpyruvate carboxykinases (PEPCKs) are critical enzymes for plant metabolism with diverse roles in plant development and growth. Multiple lines of evidence showed the complex regulation of PEPCKs, including PTMs. Herein, we present PEPCKs as an example of the integration of combined mechanisms modulating enzyme activity and metabolic pathways. PEPCK studies strongly advanced after the production of the recombinant enzyme and the establishment of standardized biochemical assays. Finally, we discuss emerging open questions for future research and the challenges in integrating all available data into functional biochemical models.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Oxford University Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Allosteric regulation  
dc.subject
Carbon metabolism  
dc.subject
Enzyme regulation  
dc.subject
Metabolic control  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Integrating multiple regulations on enzyme activity: the case of phospho enol pyruvate carboxykinases  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-08-01T13:26:59Z  
dc.journal.volume
15  
dc.journal.number
4  
dc.journal.pagination
1-11  
dc.journal.pais
Reino Unido  
dc.description.fil
Fil: Rojas, Bruno Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina  
dc.description.fil
Fil: Iglesias, Alberto Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina  
dc.journal.title
AoB PLANTS  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/aobpla/article/doi/10.1093/aobpla/plad053/7235484  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/aobpla/plad053