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dc.contributor.author
Rojas, Bruno Ezequiel
dc.contributor.author
Iglesias, Alberto Alvaro
dc.date.available
2024-08-02T12:30:44Z
dc.date.issued
2023-07
dc.identifier.citation
Rojas, Bruno Ezequiel; Iglesias, Alberto Alvaro; Integrating multiple regulations on enzyme activity: the case of phospho enol pyruvate carboxykinases; Oxford University Press; AoB PLANTS; 15; 4; 7-2023; 1-11
dc.identifier.issn
2041-2851
dc.identifier.uri
http://hdl.handle.net/11336/241595
dc.description.abstract
Data on protein post-translational modifications (PTMs) increased exponentially in the last years due to the refinement of mass spectrometry techniques and the development of databases to store and share datasets. Nevertheless, these data per se do not create comprehensive biochemical knowledge. Complementary studies on protein biochemistry are necessary to fully understand the function of these PTMs at the molecular level and beyond, for example, designing rational metabolic engineering strategies to improve crops. Phosphoenolpyruvate carboxykinases (PEPCKs) are critical enzymes for plant metabolism with diverse roles in plant development and growth. Multiple lines of evidence showed the complex regulation of PEPCKs, including PTMs. Herein, we present PEPCKs as an example of the integration of combined mechanisms modulating enzyme activity and metabolic pathways. PEPCK studies strongly advanced after the production of the recombinant enzyme and the establishment of standardized biochemical assays. Finally, we discuss emerging open questions for future research and the challenges in integrating all available data into functional biochemical models.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Allosteric regulation
dc.subject
Carbon metabolism
dc.subject
Enzyme regulation
dc.subject
Metabolic control
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Integrating multiple regulations on enzyme activity: the case of phospho enol pyruvate carboxykinases
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-08-01T13:26:59Z
dc.journal.volume
15
dc.journal.number
4
dc.journal.pagination
1-11
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Rojas, Bruno Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Iglesias, Alberto Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.journal.title
AoB PLANTS
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/aobpla/article/doi/10.1093/aobpla/plad053/7235484
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/aobpla/plad053
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