Artículo
Unraveling the crosstalk between renin‐angiotensin system receptors
Fecha de publicación:
03/2024
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Acta Physiologica
ISSN:
1748-1708
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The renin-angiotensin system (RAS) plays a key role in blood pressure regulation. The RAS is a complex interconnected system composed of two axes with opposite effects. The pressor arm, represented by angiotensin (Ang) II and the AT1 receptor (AT1R), mediates the vasoconstrictor, proliferative, hypertensive, oxidative, and pro-inflammatory effects of the RAS, while the depressor/protective arm, represented by Ang-(1-7), its Mas receptor (MasR) and the AT2 receptor (AT2R), opposes the actions elicited by the pressor arm. The AT1R, AT2R, and MasR belong to the G-protein-coupled receptor (GPCR) family. GPCRs operate not only as monomers, but they can also function in dimeric (homo and hetero) or higher-order oligomeric states. Due to the interaction with other receptors, GPCR properties may change: receptor affinity, trafficking, signaling, and its biological function may be altered. Thus, heteromerization provides a newly recognized means of modulation of receptor function, as well as crosstalk between GPCRs. This review is focused on angiotensin receptors, and how their properties are influenced by crosstalk with other receptors, adding more complexity to an already complex system and potentially opening up new therapeutic approaches.
Palabras clave:
AT1 RECEPTOR
,
AT2 RECEPTOR
,
G PROTEIN-COUPLED RECEPTOR
,
HETEROMERIZATION
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INTEQUI)
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Gironacci, Mariela Mercedes; Bruna Haupt, Ezequiel Fabricio; Unraveling the crosstalk between renin‐angiotensin system receptors; Wiley Blackwell Publishing, Inc; Acta Physiologica; 240; 5; 3-2024; 1-19
Compartir
Altmétricas